BODIPY-Based Photothermal Agents with Excellent Phototoxic Indices for Cancer Treatment.

Here, we report six novel, easily accessible BODIPY-based agents for cancer treatment. In contrast to established photodynamic therapy (PDT) agents, these BODIPY-based compounds show additional photothermal activity and their cytotoxicity is not dependent on the generation of reactive oxygen species (ROS). The agents show high photocytotoxicity upon irradiation with light and low dark toxicity in different cancer cell lines in 2D culture as well as in 3D multicellular tumor spheroids (MCTSs).

Single crystal growth of water-soluble metal complexes with the help of the nano-crystallization method.

The Nano-Crystallization method has been extensively tested for the growth of single crystals of cationic coordination compounds, which are soluble in water. All three studied, diverse metal complexes could be crystallized with the help of pipetting robots commonly used for the crystallization of proteins and the anion small molecule screen. It was furthermore possible to obtain for each positively charged complex several structures with different anions.

Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy.

We report the first exocyclically metallated tetrapyridinoporphyrazine, [tetrakis-(trans-Pt(NH)Cl)-tetra(3,4-pyrido)porphyrazine-zinc(ii)](NO) (4), synthesized in a multistep synthesis starting from 3,4-pyridinedicarbonitrile (1). The synthetic procedure involved a platination reaction of the intermediate tetra(3,4-pyrido)porphyrazine-zinc(ii) (2), whereby the zinc(ii) enhanced the solubility of the intermediate enabling the platination reaction. A similar approach to synthesize [tetrakis-(trans-Pt(NH)Cl)-tetra(3,4-pyrido)porphyrazine](NO) (5) failed due to the unsuitable solubility properties of the intermediate tetra(3,4-pyrido)porphyrazine (3).