Oxidative Transformation of 2-Furylanilines into Indolin-3-ones.

Oxidation of 2-furylaninlies with -CPBA followed by treatment with a base provides access to functionalized indolin-3-ones. The designed oxidative transformation utilizes an underassessed chemical behavior of furyl-containing amines to form a C-N bond via engaging a β-carbon atom of the furan core upon a ring-forming step, thereby providing an alternative disconnection toward nitrogen-containing heterocycles.

Synthesis, Antimicrobial and Antibiofilm Activities, and Molecular Docking Investigations of 2-(1-Indol-3-yl)-1-benzo[]imidazole Derivatives.

The treatment of many bacterial and fungal infections remains a problem due to increasing antibiotic resistance and biofilm formation by pathogens. In the present article, a methodology for the chemoselective synthesis of 2-(1-indol-3-yl)-1-benzo[]imidazole derivatives is presented. We report on the antimicrobial activity of synthesized 2-(1-indol-3-yl)-1-benzo[]imidazoles with significant activity against ATCC 25923, ATCC 43300 (MRSA), (mc(2)155/ATCC 700084), and ATCC 10231.

Interrupted Furan-Yne Cyclization: Access to Unsaturated Dicarbonyl Compounds and Their Subsequent Transformation into Functionalized Pyridazines.

The key carbenoid intermediate of transition-metal-catalyzed furan-yne cyclization in Hashmi phenol synthesis could be efficiently intercepted with water under the developed reaction conditions in order to provide access to functionalized unsaturated dicarbonyl compounds that might serve as convenient precursors for the straightforward synthesis of annulated pyridazines.

Natural epoxyquinoids: isolation, biological activity and synthesis. An update.

Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse biological activities, including, but not limited to, antibacterial, antifungal, anticancer, enzyme inhibitory, and others. The last review on their total synthesis was published in 2017. Since then, almost 100 articles have been published on their isolation from nature and their biological profile.

The Synthesis and Biological Evaluation of 2-(1-Indol-3-yl)quinazolin-4(3)-One Derivatives.

The treatment of many bacterial diseases remains a significant problem due to the increasing antibiotic resistance of their infectious agents. Among others, this is related to , especially methicillin-resistant (MRSA) and . In the present article, we report on antibacterial compounds with activity against both and MRSA.