Publications by authors named "Ekaterina Pukhlyakova"
Morphogenesis is a shape-building process during development of multicellular organisms. During this process, the establishment and modulation of cell-cell contacts play an important role. Cadherins, the major cell adhesion molecules, form adherens junctions connecting epithelial cells.
View Article and Find Full Text PDFAlthough the genetic regulation of cellular differentiation processes is well established, recent studies have revealed the role of mechanotransduction on a variety of biological processes, including regulation of gene expression. However, it remains unclear how universal and widespread mechanotransduction is in embryonic development of animals. Here, we investigate mechanosensitive gene expression during gastrulation of the starlet sea anemone , a cnidarian model organism.
View Article and Find Full Text PDFGerm-layer commitment and axis formation in sea anemone embryonic cell aggregates.
Proc Natl Acad Sci U S A
February 2018
Article Synopsis
- - Robust morphogenetic events are crucial for animal embryogenesis, but different species within a phylum can follow a broader range of developmental paths than what is seen in typical development.
- - Using microsurgery and transgenic reporter gene expression, researchers demonstrated that dissociated embryonic cells of the sea anemone can adopt an alternative development route in response to new conditions.
- - These cell aggregates depend on Wnt signals from the original organizer and exhibit significant plasticity, allowing ectodermal cells to transform into endoderm, indicating that new developmental trajectories can arise more easily when embryonic cells are highly adaptable.