Integration of suboptimal health status and endothelial dysfunction as a new aspect for risk evaluation of cardiovascular disease.

Background: Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction.