Publications by authors named "Ekaterina Koksharova"
Ultra-rapid insulin lispro is an innovative insulin analogue designed to achieve rapid onset and short duration of action, aimed at optimizing glycemic control in patients with diabetes. This was a double-blind, randomized, 2-period, crossover clamp study to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD), along with safety profiles, of a potential biosimilar ultra-rapid insulin lispro compared to the reference product in healthy White men. A total of 35 healthy volunteers completed hyperinsulinemic euglycemic clamp procedures across both study periods.
View Article and Find Full Text PDFThe aim of the study was to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of T-glu (GP40321, test drug), and reference insulin glulisine in a hyperinsulinemic-euglycemic clamp procedure. During this study, 34 healthy male volunteers underwent the hyperinsulinemic-euglycemic clamp procedure following subcutaneous 0.3 U/kg injection of T-glu or reference insulin glulisine in a randomized, double-blind, crossover study.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between primary hyperparathyroidism (PHPT) and metabolic syndrome components in young patients, highlighting significant rates of insulin resistance and excessive visceral fat.
- A comprehensive assessment before and after parathyroid surgery showed patients had higher triglycerides and insulin levels, but surgery did not lead to significant changes in lipid profiles or body composition.
- The findings suggest that PHPT is linked to insulin resistance, a major risk factor for metabolic disorders, and that surgical intervention may offer some improvements in carbohydrate and purine metabolism.
This paper presents an analysis of data from a comparative study of biosimilarity in terms of pharmacokinetics and pharmacodynamics in healthy volunteers using a hyperinsulinemic euglycemic clamp for reference and test biphasic insulin aspart 30 (BIAsp 30). As a result of the study, one of the secondary pharmacodynamic (PD) endpoints did not satisfy the classical criterion of 80%-125% (the lower limit for PD parameter area under the glucose infusion rate-time curve [ ] turned out to be 79.5%).
View Article and Find Full Text PDFDirect Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity.
Biochemistry (Mosc)
March 2021
Article Synopsis
- Incretin hormones like GLP-1 help lower glucose levels, reduce appetite, and protect the heart, but their effects on fat tissue are not fully understood.
- Researchers investigated how liraglutide, a synthetic version of GLP-1, affects fat cell development and insulin sensitivity in 3T3-L1 adipocytes.
- The study found that liraglutide improves insulin sensitivity in mature fat cells through mechanisms involving adenylate cyclase, suggesting that it has a beneficial impact on fatty tissue.
Obesity is a global problem and the most common metabolic disorder leading to many associated diseases, such as arterial hypertension, ischemic heart disease, type 2 diabetes, certain types of cancer, impaired lipid and uric acid metabolism. The prevalence of obesity has risen globally in the past four decades in both children and adults, and it accounts for the rapid increase in the prevalence of diabetes. Currently, the study of thermogenic tissues, brown and beige adipose tissues, is of extreme value from the point of view of therapeutic potential for obesity and its associated diseases.
View Article and Find Full Text PDFBackground: The association of type 2 diabetes mellitus (T2DM) with the and genes in the Russian population has not been well studied. In this study, we analysed the population frequencies of polymorphic markers of these genes.
Methods: The study included 862 patients with T2DM and 443 control subjects of Russian origin.
We report the case of a 12-year-old boy with a glucokinase () mutation, and diabetes with hyperinsulinemia and insulin resistance. For 4 years, the patient intermittently received insulin medications Actrapid HM and Protaphane HM (total dose 5 U/day), with glycated hemoglobin (HbA) levels of 6.6%-7.
View Article and Find Full Text PDFBackground: The evaluation of brown adipose tissue (BAT) and its role in metabolism and obesity remains an important topic in the recent literature. This study evaluated the influence of the BAT triglyceride content measured by proton magnetic resonance (MR) spectroscopy in patients with type 2 diabetes mellitus (DM2) and prediabetes on insulin sensitivity.
Methods: A total of 25 patients with DM2 and prediabetes (45.