Publications by authors named "Ekaterina Bunyaeva"
Purpose: To determine how clinical, demographic, and laboratory characteristics influence ovarian tissue oocyte quality.
Methods: Immature cumulus-oocyte complexes were isolated from removed ovaries and cultured for 48-52 h in either monophasic standard or biphasic CAPA media for fertility preservation. A total of 355 MII oocytes from 53 patients were described for intracytoplasmic and extracytoplasmic anomalies.
Article Synopsis
- The study investigates the possibility of maturing oocytes from oophorectomy samples in patients with malignant ovarian tumors as a way to preserve fertility, especially in the context of oncofertility.
- A total of 27 patients were included, revealing that 99 cumulus-oocyte complexes were collected from 17 patients and resulted in a maturation rate of about 40%, with some oocytes being successfully vitrified for future use.
- It is concluded that this method may be beneficial for younger patients with specific health conditions before undergoing surgery or chemotherapy, highlighting the importance of AMH levels and tumor burden in the decision-making process.
Purpose: To investigate the developmental competence of ovarian tissue oocytes from patients with gynecological tumors using a biphasic in vitro maturation system with capacitation (CAPA-IVM) in comparison with standard IVM.
Methods: This sibling pilot study included 210 oocytes in 10 patients with gynecological malignancies. After ovariectomies, ovaries were cut into even halves and immature cumulus-oocyte complexes (COCs) were retrieved from the ovarian tissue.
With the increased rate of stable remission after gonadotoxic cancer treatment, new methods of fertility preservation are required in order to provide the best possible care for oncological patients. Here, we report an original case of euploid blastocyst cryopreservation after in vitro maturation of ovarian tissue oocytes (OTO IVM). Thirty-three oocytes were obtained from the ovarian tissue after ovariectomy in the breast cancer patient.
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