The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren's Syndrome.

Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the loss of self-tolerance mechanisms in various autoimmune diseases, including primary Sjögren's syndrome (pSS). With the development of pSS primarily in the exocrine glands, lymphocytic infiltration occurs in the early stages, mainly due to activated CD4 T cells. Subsequently, in the absence of rational therapy, patients develop ectopic lymphoid structures and lymphomas.