Publications by authors named "Ekaterina A Polteva"
Template activating factor-I (TAF-I) is a multifunctional protein involved in various biological processes including the inhibition of histone acetylation, DNA replication, cell cycle regulation, and oncogenesis. Two main TAF-I isoforms with different N-termini, TAF-Iα and TAF-Iβ (SET), are expressed in cells. There are numerous data about functional properties of TAF-Iβ, whereas the effects of TAF-Iα remain largely unexplored.
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- The TRIM14 protein is involved in both antiviral defense and cancer processes, affecting apoptosis in different ways depending on the type of tumor cells.
- A study investigated the role of human TRIM14 and its mutant form in inducing apoptosis in transgenic loach embryos, revealing increased apoptosis associated with both forms of the gene.
- The findings suggest that TRIM14 promotes cell death during embryonic development through the activation of certain proapoptotic genes, with the mutant version following a different, p53-independent pathway.