Genome Wide Identification and Comparative Analysis of the Serpin Gene Family in Brachypodium and Barley.

Serpins (serine protease inhibitors) constitute one of the largest and most widely distributed superfamilies of protease inhibitors and have been identified in nearly all organisms. To gain significant insights, a comprehensive in silico analysis of the serpin gene family was carried out in the model plant for temperate grasses and barley using bioinformatic tools at the genome level for the first time. We identified a total of 27 BdSRPs and 25 HvSRP genes in and barley, respectively, showing an unexpectedly high gene number in these model plants.

Identification of novel mutations in SARS-COV-2 isolates from Turkey.

SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions.

An overview on red algae bioactive compounds and their pharmaceutical applications.

Objectives To review red algae bioactive compounds and their pharmaceutical applications. Content Seaweed sources are becoming attractive to be used in health and therapeutics. Among these red algae is the largest group containing bioactive compounds utilized in cosmetic, pharmaceutical, food industry, manure and various supplements in food formula.

Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer.

Objective: To investigate the phytochemicals and in vitro antioxidant, antimicrobial and cytotoxic potential of Rumex dentatus (R. dentatus) leaf extracts.

Methods: The total phenolics and flavonoids content of R.

Xanthophyll: Health benefits and therapeutic insights.

Xanthophylls constitute a major part of carotenoids in nature. They are an oxidized version of carotenoid. Xanthophyll has widely drawn scientists' attentions in terms of its functionality, bioavailability and diversity.

Expression analysis of the polyphenol oxidase gene in response to signaling molecules, herbivory and wounding in antisense transgenic tobacco plants.

Key Message: We provide evidence that the expression of the gene was significantly reduced in response to wounding, MeJ and herbivory in transgenic tobacco under wound-inducible RGLP2 promoter in an anti-sense orientation.

Abstract: Polyphenol oxidase (PPO) genes play an important role in plant defense mechanisms against biotic and abiotic stresses. In the present study, a 655 bp core sequence of the potato gene was placed under the control of wound-inducible RGLP2 promoter in an anti-sense direction to evaluate its potential effects during biotic ('s infestation) and various abiotic (wounding, MeJ, ABA) stresses.

Expression analysis of proteinase inhibitor-II under RGLP2 promoter in response to wounding and signaling molecules in transgenic .

Proteinase inhibitor-II (PI-II) genes are important defense related genes that play critical regulatory roles in plant growth and development. In the present study, the expression of tomato gene was investigated under the control of a wound-inducible RGLP2 ( root germin like protein 2) promoter in transgenic tobacco plants after wounding, ABA and MeJA applications. Transcript level of target gene in transgenic plants was confirmed by quantitative real time PCR (qPCR).

Inhibits Cell Proliferation, Arrests Cell Cycle, and Induces Apoptosis in MDA-MB-231 Cells through Suppression of the NF-κB Pathway.

, commonly known as tooth docked, is widely used in traditional system of medicines. Although it is well reported for its biological activities and medicinal value, only few studies have been carried out to assess its anticancer potential. This study seeks to evaluate the anticancer activity of leaf extracts of against breast cancer MDA-MB-231 cell line, a triple negative human breast cancer cell line with invasive properties and to identify the molecular targets underlying its mechanism of action.

Structural and functional characteristics of plant proteinase inhibitor-II (PI-II) family.

Plant proteinase inhibitor-II (PI-II) proteins are one of the promising defensive proteins that helped the plants to resist against different kinds of unfavorable conditions. Different roles for PI-II have been suggested such as regulation of endogenous proteases, modulation of plant growth and developmental processes and mediating stress responses. The basic knowledge on genetic and molecular diversity of these proteins has provided significant insight into their gene structure and evolutionary relationships in various members of this family.

Computational analysis of atpB gene promoter from different Pakistani apple varieties.

Apple is the fourth most important fruit crop grown in temperate areas of the world belongs to the family Rosaceae. In the present study, the promoter (∼1000bp) region of atpB gene was used to evaluate the genetic diversity and phylogeny of six local apple varieties. atpB gene is one of the large chloroplastic region which encodes β-subunit of ATP synthase and previously it had been used largely in phylogenetic studies.