Publications by authors named "Ejaz Alam"
Article Synopsis
- Pakistan has one of the highest hepatitis C burdens globally, with a serosurvey revealing the need to compare current prevalence rates to 2008 data.
- The study tested 6,672 individuals in Sindh Province and found that 1% were hepatitis positive, with rising prevalence linked to age and certain risk factors like family history and barber shaving.
- Recommendations include implementing mass testing and treatment strategies in a collaborative manner to stop hepatitis spread and prevent severe liver disease outcomes.
Article Synopsis
- Pakistan has a significant burden of hepatitis B (HBV) and hepatitis C (HCV) infections, with various studies conducted to track progress towards their elimination.
- Between 2007 and 2019 in Sindh province, HBV prevalence dropped significantly from 2.6% to 1.1%, whereas HCV exposure increased from 5.1% to 6.2%, particularly among adults.
- Key risk factors for HCV include medical injections, blood transfusions, and family history of hepatitis, with modifiable factors responsible for nearly half of HCV exposures, highlighting the need for targeted prevention efforts.
Karachi Cancer Registry (KCR): Consolidated Data of 5-years 2017-2021.
J Coll Physicians Surg Pak
May 2023
Objective: To collect and analyse epidemiologic data of all malignancies by age group and gender for the Karachi population to estimate the cancer incidence of 5-years (2017-2021) and identify major risk factors for setting priorities towards cancer control programs.
Study Design: Observational study. Place and Duration of the Study: Karachi Cancer Registry (KCR) Secretariat, Pakistan Health Research Council (PHRC), JPMC, Karachi, from 2017-2021.
Objectives: To estimate the cancer incidence by age group and gender for the population of Karachi Division by analyzing the Karachi Cancer Registry data of 2017-19.
Settings: The population of Karachi division is 16.1 million according to national census 2017.
Response to different conventional interferons in treatment of chronic hepatitis C.
J Ayub Med Coll Abbottabad
May 2014
Background: Sustained virological response to interferon therapy is a great challenge for patients of chronic Hepatitis C. Over 20 brands of interferons are available in the local market with each claiming over 80% response and a wide variation in the cost thus creating confusion for treating physicians as to which drug should be selected.
Methods: Chronic Hepatitis C patients attending outpatients department of Pakistan Medical Research Centre JPMC from January 1998-December 2010 were evaluated.
Background: The cytokines that act as inflammatory hormones show a role in coronary atherosclerotic disease.
Aims: This study aimed to measure serum resistin, IL-6 levels and lipid profile in nondiabetic controls, diabetics, and ischemic heart disease subjects with and without diabetes. Association between resistin and IL-6 was also determined.
Objective: To integrate informal registered medical practitioners (IRMP) in Directly Observed Therapy Short Course (DOTS) implementation to improve case detection rate.
Methods: This interventional study was conducted in the settlement area of Malir district whereas New Karachi was taken as control, between February to November 2005. All registered healthcare providers within 5 kilometer around Tuberculosis (TB) DOTS center Malir were included.
Objective: To investigate whether hypo-adiponectinemia is present in ischemic stroke patients.
Methods: This comparative study was carried out in the Biochemistry Department, Ziauddin University, Karachi, Pakistan in 2008. In this study, plasma adiponectin concentration was measured by an enzyme-linked immunosorbent assay in subjects with and without ischemic cerebrovascular disease (CVD).
Objective: To see effect of Lamivudine on sero conversion of HBeAg positive cases co infected with Delta hepatitis.
Methods: Hepatitis B positive patients with deranged liver functions for 6 months were tested for HBeAg, HBV DNA and anti-Delta virus (HDV), using ELISA. Patients were divided into 2 groups, group 1: HBeAg, HBV DNA positive (wild type) but delta negative and group 2: HBeAg, HBV DNA positive (wild type) with delta positive.
Objective: To study the exposure of HCV in the spouses of patients suffering from chronic hepatitis C virus infection attending the outpatients department of medical research center running a liver clinic.
Methods: Index patients were defined as patients suffering from hepatitis C related chronic liver disease. HCV infection was confirmed by a 3rd generation kit, chronic liver disease by raised alanine amino transferase for over 6 months.
Objective: To determine adiponectin, leptin and blood lipid levels in normal and obese postmenopausal women and to compare them.
Methods: Eighty postmenopausal women were selected which included 40 normal controls and 40 obese women matched for age and height. Adiponectin and leptin levels were determined by ELISA.
Objective: To identify the morbidity pattern according to age, gender and seasonal variation using the ICD coding and the utilization of Primary Health Care (PHC) center services in a demographically defined community.
Methods: The data collected from 2001-2003 was analyzed using the International Classification of Diseases-10 (ICD-10) coding for identifying the morbidity patterns presenting at the PHC Center. The age and gender distribution of the patients and the seasonal variation of few diseases were noted.