Fluoroalkylated hypervalent sulfur fluorides: radical addition of arylchlorotetrafluoro-λ-sulfanes to tetrafluoroethylene.

Fluorinated groups are essential hydrophobic groups in drug design. Combining a carbon-free tetrafluoro-λ-sulfanyl (SF) group with a polyfluoroalkyl group (R) provides SFR groups, exhibiting high hydrophobicity with a short carbon chain. In this study, various aryltetrafluoro(polyfluoroalkyl)-λ-sulfanes (ArSFR) were synthesized through the radical addition of arylchlorotetrafluoro-λ-sulfanes (ArSFCl) to tetrafluoroethylene.