Publications by authors named "Eirini Kalliara"
Article Synopsis
- Mycosis fungoides (MF) is a rare skin cancer that progresses slowly in early stages but can vary greatly in treatment response and life expectancy once advanced.
- The BIO-MUSE trial aims to identify specific markers for disease progression using advanced molecular analysis techniques, analyzing tissue and blood samples from a patient over time.
- Findings highlight potential targets for treatment, such as transforming growth factor β1, suggesting that studying the cancer's evolution alongside the immune response may improve future interventions.
Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need.
View Article and Find Full Text PDFImmune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonstrate that transient exposure to IFN-γ stimulation induces a long-term desensitisation of STAT1 signalling and gene expression responses, revealing a dose- and time-dependent regulatory feedback that controls JAK-STAT responses upon re-exposure to stimulus.
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