Publications by authors named "Eilis Carroll"
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure. A critical step in the pathway is the monoubiquitination of FANCD2 by the RING E3 ligase FANCL.
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- Cisplatin is an important genotoxin used in chemotherapy for solid tumors, but the underlying mechanisms of its effectiveness are not fully understood.
- Research revealed that the E3 ubiquitin ligase HOIP plays a crucial role in regulating the cell's response to cisplatin, as cells lacking HOIP are more sensitive to the drug due to increased apoptosis.
- The study suggests targeting HOIP in cancer therapies could enhance the effectiveness of cisplatin, especially in hard-to-treat cisplatin-resistant ovarian cancer cells.
Neuroblastoma, a malignancy of neuroectoderrmal origin, accounts for 15% of childhood cancer deaths. Despite advances in understanding the biology, it remains one of the most difficult paediatric cancers to treat. A major obstacle in the effective treatment of neuroblastoma is the development of multidrug resistance (MDR).
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