Publications by authors named "Eileen Ho"
J Leukoc Biol
October 2024
Article Synopsis
- Macrophages and osteoclasts, which are crucial for bone health, rely on CSF1R signaling for their growth and survival.
- Mutations in Csf1 and Csf1r lead to osteopetrosis, characterized by reduced osteoclasts and, consequently, impaired bone resorption.
- A study in rats with Csf1r mutations showed that transferring healthy bone marrow helped restore bone development and highlighted the importance of osteal macrophages in normal bone growth.
