Publications by authors named "Eileen F Serrano"

Background: A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" to guide the global response. We aimed to characterize the longitudinal dynamics of the antibody responses in naturally infected individuals in Chile and compared them to humoral responses induced after immunization with CoronaVac-based on an inactivated whole virus -or the BNT162b2- based on mRNA-vaccines. We also contrasted them with the respective effectiveness and efficacy data available for both vaccines.

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The Omicron variant of SARS-CoV-2 has been shown to evade neutralizing antibodies elicited by vaccination or infection. Despite the global spread of the Omicron variant, even among highly vaccinated populations, death rates have not increased concomitantly. These data suggest that immune mechanisms beyond antibody-mediated virus neutralization may protect against severe disease.

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Despite the dramatic spread of Omicron globally, even among highly vaccinated populations, death rates have not increased concomitantly. These data argue that alternative immune mechanisms, beyond neutralization, may continue to confer protection against severe disease. Beyond their ability to bind and block infection, antibodies contribute to control and clearance of multiple infections via their ability to direct antiviral immunity via Fc-effector mechanisms.

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Article Synopsis
  • Patients previously infected with SARS-CoV-2 develop strong neutralizing antibody (nAb) responses, peaking around 3-4 weeks after symptom onset, and these responses can last for up to 12 months.
  • Vaccination can significantly boost nAb levels in individuals who were previously infected, with two doses of CoronaVac or one dose of BNT162b2 strengthening the immune response, although some groups, like obese individuals, may not respond as well.
  • Naïve individuals receiving the same vaccine doses achieve nAb levels comparable to those of recovered patients months after natural infection, highlighting the need for two doses of CoronaVac for effective immunity in both groups.
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