Publications by authors named "Eiko Kitayama"
Article Synopsis
- Rats produce two types of ultrasonic vocalizations: positive (high pitch) and negative (low pitch), and researchers investigated these sounds in a rat model of schizophrenia.
- The model was created by administering an inflammatory cytokine to young rats, resulting in behaviors similar to those seen in schizophrenia patients.
- Findings revealed that these model rats exhibited more frequent low pitch self-triggered vocalizations than controls, but this difference disappeared with risperidone treatment, indicating a potential link between these vocalizations and schizophrenia-like symptoms.
Clozapine is an antipsychotic agent prescribed to psychotic patients exhibiting tolerance and/or resistance to the conventional antipsychotic medications that mainly drive monoamine antagonism. As the pharmacological fundamentals of its unique antipsychotic profile have been unrevealed, here, we attempted to obtain hints at this question. Here, we found that clozapine directly acts on ErbB kinases to downregulate epidermal growth factor (EGF)/neuregulin signaling.
View Article and Find Full Text PDFPerinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, and is used for animal models of schizophrenia. Patients with schizophrenia often display a reduction of mismatch negativity (MMN), which is a stimulus-change specific event-related brain potential. Do the EGF model animals also exhibit the MMN reduction as schizophrenic patients do? This study addressed this question to verify the pathophysiological validity of this model.
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