Publications by authors named "Eike Latz"
Article Synopsis
- - Microglia play a vital role in brain health by connecting to neurons through tunneling nanotubes (TNTs), allowing the quick exchange of essential materials.
- - In neurodegenerative diseases, microglia utilize these TNTs to help neurons eliminate toxic protein aggregates like alpha-synuclein and tau, thereby improving neuronal health and function.
- - Genetic mutations in microglia, such as Lrrk2(Gly2019Ser) and Trem2 variants, hinder their ability to transfer protective materials to neurons, highlighting their potential involvement in neurodegenerative disease progression.
Aortic valve stenosis (AS) development is driven by distinct molecular and cellular mechanisms which include inflammatory pathways. Toll-like-receptor-3 (TLR3) is a lysosomal pattern-recognition receptor that binds double-stranded RNA and promotes pro-inflammatory cellular responses. In recent years, TLR3 has emerged as a major regulator of vascular inflammation.
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