In the treatment of primary central nervous system lymphoma (PCNSL), intraoperative rapid pathological diagnosis can dramatically change the surgical strategy, and more accurate diagnostic methods are required. In April 2020, we adopted intraoperative rapid immunohistochemistry (IHC) in addition to conventional rapid intraoperative diagnosis based on morphological assessment, mainly for patients with PCNSL. Here, we investigate the usefulness and significance of intraoperative rapid IHC based on our initial experience.
View Article and Find Full Text PDFA turnover number (TON) of 2 400 000 and a turnover frequency (TOF) of 63 s are achieved with the chiral Ru complex 1 (R=p-CH C H ) in the asymmetric hydrogenation of acetophenone. Carbonyl-selective asymmetric hydrogenation of α,β-unsaturated ketones proceeds in the presence of these Ru catalysts, and 4-substituted cyclohexanones are selectively converted into cis alcohols.
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