Discovery of Potent Indolyl-Hydrazones as Kinase Inhibitors for Breast Cancer: Synthesis, X-ray Single-Crystal Analysis, and In Vitro and In Vivo Anti-Cancer Activity Evaluation.

According to data provided by the World Health Organization (WHO), a total of 2.3 million women across the globe received a diagnosis of breast cancer in the year 2020, and among these cases, 685,000 resulted in fatalities. As the incidence of breast cancer statistics continues to rise, it is imperative to explore new avenues in the ongoing battle against this disease.

Evaluation of the Impact of Two Thiadiazole Derivatives on the Dissolution Behavior of Mild Steel in Acidic Environments.

In light of the variety of industrial uses and economic relevance of mild steel, corrosion resistance is a serious topic. Utilization of inhibitors serves as one of the most essential methods for corrosion control. Two thiadiazole compounds, namely, 2-amino-5-(4-bromobenzyl)-1,3,4-thiadiazole () and 2-amino-5-(3-nitrophenyl)-1,3,4-thiadiazole (), were synthesized.

Synthesis of New Bioactive Indolyl-1,2,4-Triazole Hybrids As Dual Inhibitors for EGFR/PARP-1 Targeting Breast and Liver Cancer Cells.

Cancer is the most severe disease worldwide. Every year, tens of millions of people are diagnosed with cancer, and over half of those people will ultimately die from the disease. Hence, the discovery of new inhibitors for fighting cancer is necessary.

Synthesis of new 2-amino-1,3,4-oxadiazole derivatives with - activity evaluation.

Reaction of phenyl acetic acid derivatives with thiosemicarbazide in the presence of POCl afforded 5-(4-bromobenzyl)-1,3,4-oxadiazole-2-amine and 5-(3-nitrophenyl)-1,3,4-oxadiazole -2-amine . Acylation of the amino group of oxadiazoles and with some acid chlorides such as methyl 4-(chlorocarbonyl) benzoate, 3-nitrobenzoyl chloride, 4-methoxy-benzoyl chloride, 4-isobutylbenzoyl chloride and chloroacetyl chloride yielded the acylated compounds -. Cyclization of acetamides and by reaction with ammonium thiocyanate gave the thiazolidinones and .