Publications by authors named "Eich D"

Attention-deficit/hyperactivity disorder (ADHD) affects approximately 12% of children worldwide. With a 50% chance of persistence into adulthood and associations with impairments in various domains, including social and emotional ones, early diagnosis is crucial. The exact neural substrates of ADHD are still unclear.

View Article and Find Full Text PDF

Vigilance refers to the ability to maintain attention and to remain alert to stimuli in prolonged and monotonous tasks. Vigilance decrement describes the decline in performance in the course of such sustained attention tasks. Time-related alterations in attention have been found to be associated with changes in EEG.

View Article and Find Full Text PDF

Considering the high clinical and forensic relevance of pharmaco-adherence during lisdexamphetamine (LDX) treatment for attention-deficit/hyperactivity disorder (ADHD), the aim here was to evaluate hair analysis as a tool for monitoring compliance in patients currently undergoing long term treatment with LDX, by detecting possible interruptions of medication intake or changes in dosage. For this purpose, a total of 24 patients from an outpatient clinic for ADHD were recruited. Hair and urine samples were taken after three consecutive therapy sessions over a 7-month period and analyzed for amphetamine (AMP) enantiomers and other drugs, using chiral and achiral liquid chromatography-tandem mass spectrometry (LC-MS/MS).

View Article and Find Full Text PDF

This study aimed to re-evaluate the possible differences between attention-deficit/hyperactivity disorder (ADHD) subjects and healthy controls in the context of a standard Go/NoGo task (visual continuous performance test [VCPT]), frequently used to measure executive functions. In contrast to many previous studies, our sample comprises children, adolescents, and adults. We analyzed data from 447 ADHD patients and 227 healthy controls.

View Article and Find Full Text PDF

We present three-dimensional simulations of HgCdTe-based focal plane arrays (FPAs) with two-color and dual-band sequential infrared pixels having realistic truncated-pyramid shape, taking into account also the presence of compositionally graded transition layers. After a validation against the spectral responsivity of two-color, mid-wavelength infrared detectors from the literature, the method is employed for a simulation campaign on dual-band, mid-, and long-wavelength infrared FPAs illuminated by a Gaussian beam. Simulation results underscore the importance of a full-wave approach to the electromagnetic problem, since multiple internal reflections due to metallizations and slanted sidewalls produce non-negligible features in the quantum efficiency spectra, especially in the long-wavelength band.

View Article and Find Full Text PDF

Majority carrier depletion has been proposed as a method to suppress the dark current originating from quasi-neutral regions in HgCdTe infrared focal plane array detectors. However, a very low doping level is usually required for the absorber layer, a task quite difficult to achieve in realizations. In order to address this point, we performed combined electromagnetic and electric simulations of a planar $ 5 \times 5 $5×5 pixel miniarray with 5 µm wide square pixels, assessing the effect of the absorber thickness, its doping level in the interval $ {N_D}{ = [10^{14}}{,10^{15}}] \;{{\rm cm}^{ - 3}} $N=[10,10]cm, and temperature in the interval 140 K-230 K, both in the dark and under illumination.

View Article and Find Full Text PDF

The electrophysiological characteristics of attention-deficit/hyperactivity disorder (ADHD) and recent machine-learning methods promise easy-to-use approaches that can complement existing diagnostic tools when sufficiently large samples are used. Neuroalgorithms are models of multidimensional brain networks by means of which ADHD patient data can be separated from healthy control data. Spontaneous electroencephalographic and event-related potential (ERP) data were collected three times over the course of 2 years from a multicentre sample of adults comprising 181 patients with ADHD and 147 healthy controls.

View Article and Find Full Text PDF

Objective: The primary objectives of this study were to investigate how adult patients with ADHD coped with their symptoms prior to diagnosis and treatment, what skills and compensation strategies they had developed and what their self-perceptions of these strategies were.

Methods: We used a qualitative approach to analyze interviews with 32 outpatients of a specialty care unit at a university hospital.

Results: Patients reported frequent use of diverse compensatory strategies with varying degrees of effectiveness.

View Article and Find Full Text PDF

Aim: The objective of this study was to investigate how adult patients with attention-deficit/hyperactivity disorder viewed the testing and use of stimulants in their children.

Methods: Using a qualitative approach, we interviewed 32 outpatients from a special care unit of a university hospital.

Results: Emerging themes centered around concerns about the right age to test children and opinions about stimulant treatment ranging from unreserved agreement to reluctance, as well as the need for a shared decision with the child.

View Article and Find Full Text PDF

Background: Nicotine use has been reported to ameliorate symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD). Furthermore, adults with ADHD have a relatively high prevalence of cigarette smoking and greater difficulty abstaining from smoking. Overall, though, there is scant literature investigating the beliefs, perceptions and experiences of smokers with ADHD regarding smoking cessation and withdrawal.

View Article and Find Full Text PDF

ADHD is the one of the most prevalent childhood disorders and has been associated with impairments persisting into adulthood. Specifically, childhood ADHD is an independent clinical risk factor for the development of later substance use disorders (SUD). Moreover, adults who meet diagnostic criteria for ADHD have shown high rates of comorbid SUDs.

View Article and Find Full Text PDF

Background: The relationship between borderline personality disorder (BPD), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD) requires further elucidation.

Methods: Seventy-four adult psychiatric in- and out-patients, each of them having received one of these diagnoses on clinical assessment, were interviewed and compared in terms of diagnostic overlap, age and sex distribution, comorbid substance, anxiety and eating disorders, and affective temperament.

Results: Diagnostic overlap within the three disorders was 54%.

View Article and Find Full Text PDF

Background: Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with high rates of comorbid substance use disorders, and cigarette smoking has a particularly high prevalence in this population. However, there is an ongoing debate as to whether this tobacco use is an attempt at "self-medication" or due to behavioral disinhibition. There is a surprising lack of qualitative studies that investigate the subjective perceptions of adults with ADHD regarding cigarette smoking.

View Article and Find Full Text PDF

Even though there is an impaired perceptual capacity in attention-deficit/hyperactivity disorder (ADHD) patients, psychophysiological alterations, such as impaired gating as indexed by prepulse inhibition (PPI) or suppression of P50 auditory event-related potentials, have not been found in patients with ADHD. Hence, potential relationships of psychophysiological measures of gating to psychopathology and cognitive performance remain unclear. The present study investigates two distinct operational measures of gating as well as cognitive performance within adult ADHD patients in order to assess the relationship of these measures to psychopathology.

View Article and Find Full Text PDF

Introduction: Stimulant medication improves hyperactivity, inattention, and impulsivity in both pediatric and adult populations with Attention Deficit Hyperactivity Disorder (ADHD). However, data regarding the optimal dosage in adults is still limited.

Case Presentation: We report the case of a 38-year-old Caucasian patient who was diagnosed with Attention Deficit Hyperactivity Disorder when he was nine years old.

View Article and Find Full Text PDF

Attention deficit hyperactivity disorder (ADHD) in adults is increasingly recognized as a clinically important syndrome. The aim of this study was to evaluate the psychometric performance of a new scale for adult ADHD based on the widely used Symptom Checklist 90 Revised (SCL-90-R). Scale performance was assessed in a clinical study including 100 ADHD patients and 65 opiate-dependent patient controls, and in the Zurich study, an epidemiological age cohort followed over 30 years of adult life.

View Article and Find Full Text PDF

Little is known about bone mineral density (BMD) in patients with heroin addiction and subsequent methadone substitution. The goal of this study was to compare bone mass density of young HIV-negative women on long-term methadone treatment to a local group of young healthy women. Eleven women (aged 20-29) with previous heroin dependence and current methadone substitution (20-140 mg, median 60, daily) for 1.

View Article and Find Full Text PDF

Objective: Research in the USA has demonstrated numerous associations between adult attention-deficit/hyperactivity disorder (ADHD) and smoking behaviour; however, no specific work on this topic has been done in Switzerland. The aim of the study was to gain knowledge about the association between ADHD and tobacco consumption in a Swiss sample of adult ADHD patients.

Methods: The study subjects were recruited from patients with a DSM-IV diagnosis of ADHD consecutively presenting to the ADHD consultation service at the Centre for Addiction Disorders, an outpatient facility of the Zurich University Hospital, between September 2000 and January 2006.

View Article and Find Full Text PDF

Study Objectives: (1) To describe the prevalence and prospective course of insomnia in a representative young-adult sample and (2) to describe the cross-sectional and longitudinal associations between insomnia and depression.

Design: Longitudinal cohort study.

Setting: Community of Zurich, Switzerland.

View Article and Find Full Text PDF

Background: Smoking rates in methadone-maintained patients are almost three times higher than in the general population and remain elevated and stable. Due to the various negative health effects of smoking, nicotine dependence contributes to the high mortality in this patient group. The purpose of the current study was to investigate Swiss methadone and buprenorphine-maintained patients' willingness to stop smoking and to clarify further smoking cessation procedures.

View Article and Find Full Text PDF

Background: The objective of this longitudinal study was to assess the association between major depression and heart complaints in a population of young and healthy adults.

Methods: Starting at the age 20/21, participants of the Zurich Study underwent 6 structured, psychological interviews during a span of 20 years. We evaluated longitudinal data from 277 persons who participated in all 6 interviews including questions about heart complaints.

View Article and Find Full Text PDF

Purpose: Recent work suggested that psychosis might be expressed at subclinical levels. However, the determinants of subclinical psychotic symptoms, the degree of continuity over the life span, and the impact on functioning remain unclear. Thus we analyzed the prevalence, determinants, patterns and impact of subclinical psychotic symptoms in a community cohort over a 20-year period.

View Article and Find Full Text PDF

Objective: To expand the concept of recurrent brief depression (RBD) to brief depression (BD) and to test its clinical relevance.

Method: Subjects (N = 591) were studied prospectively six times from ages 20/21 to 40/41 years. RBD was defined according to DSM-IV as episodes under 2 weeks with about monthly recurrence and work impairment.

View Article and Find Full Text PDF