Effect of light cycle on 24-hour pattern of mouse intraocular pressure.

Purpose: The present study was undertaken to determine the magnitude, dynamic pattern, and synchrony of the 24-hour pattern of intraocular pressure (IOP), and to clarify the effect of light cycle on 24-hour pattern of IOP in ddY albino mice.

Methods: Three groups of ddY albino mice were exposed to a 12-hour light/dark cycle (control group), to constant light and, to constant dark, respectively. Every group was exposed to each condition for 4 weeks before IOP measurements.

Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation.

Purpose: To establish a mouse model for the pharmacological analysis of antiglaucoma drugs, considering the effect of variations in IOP during 24 hours on the drugs' effects, and to evaluate the effect of a newly developed FP agonist, tafluprost, on mouse IOP, in comparison with three clinically available prostaglandin (PG) analogues.

Methods: Inbred adult ddY mice were bred and acclimatized under a 12-hour light-dark cycle. With mice under general anesthesia, a microneedle method was used to measure IOP.