Publications by authors named "Ei Kataoka"
Background/aims: Gastric acid secretion is suspected to be a pivotal contributor to the pathogenesis of functional dyspepsia. The present study investigates the potential association of the gastric acid secretion estimated by measuring serum pepsinogen with therapeutic responsiveness to the prokinetic drug acotiamide.
Methods: Dyspeptic patients consulting participating clinics from October 2017 to March 2019 were prospectively enrolled in the study.
Article Synopsis
- Local recurrence after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) is a significant issue, and the study aimed to evaluate the effectiveness of contrast-enhanced ultrasound (CE-US) with Sonazoid(®) in improving treatment outcomes.
- The study compared two groups: 31 nodules treated without CE-US and 71 with CE-US, finding that the latter group had significantly better treatment results in terms of radicality and lower local recurrence.
- The conclusion highlights that CE-US with Sonazoid(®) enhances the precision of HCC detection before and during RFA, leading to better treatment effectiveness and reduced chances of cancer recurrence.
Skull metastasis from hepatocellular carcinoma with chronic hepatitis B.
World J Gastrointest Oncol
March 2010
A 56-year-old male visited our hospital for evaluation of an occipital mass. Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver. Magnetic resonance imaging showed bone metastasis in the thoracic vertebrae.
View Article and Find Full Text PDFAim: Nonalcoholic fatty liver disease (NAFLD) is considered to be a public health problem worldwide. NAFLD is more prevalent in men than in women. Tamoxifen, a potent estrogen receptor antagonist, causes nonalcoholic steatohepatitis (NASH), a severe form of NAFLD.
View Article and Find Full Text PDFBackground/aims: Eicosapentaenoic acid (EPA) has been known as a reagent for improving lipid metabolism and inflammation. Hepatocyte-specific Pten-deficient mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). Therefore, we administered EPA to Pten-deficient mice to investigate the mechanisms of NASH.
View Article and Find Full Text PDFMao is one component of various traditional herbal medicines. We examined the effects of Mao on an acute liver failure model treated with d-galactosamine (GalN) and lipopolysaccharide (LPS). The lethality of mice administrated Mao with GalN/LPS was significantly decreased compared with that in mice without Mao.
View Article and Find Full Text PDFNon-alcoholic steatohepatitis (NASH) is a term used to describe a spectrum of conditions characterized by histological findings of hepatic macrovesicular steatosis with inflammation in individuals who consume little or no alcohol. The NASH patients progress to liver cirrhosis and even hepatocellular carcinoma (HCC). Hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice (PTEN-deficient mice), which the authors had generated previously, showed massive hepatomegaly and steatohepatitis with triglyceride accumulation followed by liver fibrosis and HCC, a phenotype similar to human NASH.
View Article and Find Full Text PDFA 72-year-old male visited our hospital for further evaluation of esophageal varices. Telangiectasias were present in the stomach. He had recurrent epistaxis, which was also confirmed in his family's medical history.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the protective effects of zinc L-carnosine on gastric mucosa in rats with portal hypertensive gastropathy (PHG), which is linked to increased gastric injuries.
- Researchers induced PHG in rats and evaluated the expression of heat shock protein (hsp) 72 after administering different forms of zinc and L-carnosine.
- Results showed that zinc L-carnosine not only increased hsp72 levels but also significantly prevented acid-induced damage to the gastric mucosa, suggesting its potential benefits for mucosal protection in PHG.
Article Synopsis
- Pten KO mice, lacking the Pten gene in liver cells, show liver damage similar to that seen in some human Non-Alcoholic Steatohepatitis (NASH) patients.
- Researchers used DNA microarray technology to analyze gene expression in these mice, identifying several candidate genes linked to inflammation, fibrosis, and potential cancer development related to NASH.
- Key genes associated with inflammation included Spp1 and Itga6, while Spp1 and Ctgf were linked to fibrosis, and Cidec and Spp1 to carcinogenesis; further studies on human liver samples are necessary to confirm these findings.
Article Synopsis
- - Epimorphin is a protein produced by hepatic stellate cells that plays a crucial role in liver development and response to liver damage.
- - The study examined how epimorphin expression varies between quiescent and activated stellate cells during liver injury and regeneration using mouse models.
- - It was found that epimorphin is predominantly expressed in quiescent stellate cells and increases during the recovery phases after liver injury, indicating its role in maintaining and repairing liver structure.
Article Synopsis
- Suramin, a compound derived from urea, was studied for its potential effects on inflammatory cytokines in an acute liver injury model induced by d-galactosamine and lipopolysaccharide.
- The study found that mice treated with suramin had significantly lower levels of inflammatory markers (TNF-alpha and IL-6) and improved survival rates, indicating a protective effect against liver damage.
- In laboratory tests, suramin was shown to inhibit the production of TNF-alpha and IL-6 by macrophages, suggesting its mechanism of action involves suppressing NF-kappaB activity, thereby presenting a potential therapeutic avenue for acute liver injury.
Article Synopsis
- - Genipin, a metabolite from the herbal medicine Inchinko-to, shows potential in reducing acute liver injury by affecting inflammatory cytokines.
- - In experiments with mice, those treated with genipin had a significantly higher survival rate and lower liver damage compared to those that did not receive treatment after exposure to GalN/LPS.
- - The study concluded that genipin improves acute liver dysfunction primarily by suppressing TNF-alpha production, while it does not significantly impact other cytokines like IL-6 and IL-1beta.
Article Synopsis
- Epimorphin, a key factor for organ development, plays a crucial role in the repair of liver tissue after injury, as shown in a study involving mice with liver damage induced by carbon tetrachloride.
- The research found that epimorphin expression varied significantly over time, with a decrease after 24 hours followed by an increase on day 7, while its presence correlated negatively with the proliferation of hepatocytes.
- In laboratory tests, epimorphin promoted the formation of spherical aggregates in liver cells and helped sustain their functionality, indicating its importance in hepatic tissue repair processes.
Background: Gabexate mesilate, a synthetic protease inhibitor, is used to treat acute pancreatitis and disseminated intravascular coagulation because it inhibits various serine proteases; however, whether gabexate mesilate prevents acute liver failure has not yet been studied. The aim of the present study was to investigate the effect of gabexate mesilate in carbon tetrachloride (CCl4)-induced liver injury in rats.
Methods: Acute hepatic failure was induced by administration of CCl4 intragastrically to male Sprague-Dawley rats.
Background: Portal hypertensive gastropathy (PHG) is a clinical entity that is observed frequently in patients with liver cirrhosis. In PHG, gastric mucosa is highly susceptible to mucosal injury caused by noxious agents. Many studies, including ours, have reported that a 72-kDa heat shock protein (HSP72) has a crucial cytoprotective function in gastric mucosa.
View Article and Find Full Text PDFBackground And Aim: A 70-kDa heat shock protein (stress-inducible HSP70, HSP72) has been reported to be a cytoprotectant in a variety of organs. It has been reported that HSP72 protected non-cirrhotic rats against endotoxemia. However, its cytoprotective effect against endotoxemia in cirrhotic rats has not yet been studied.
View Article and Find Full Text PDFPTEN is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to generate a hepatocyte-specific null mutation of Pten in mice (AlbCrePten(flox/flox) mice). AlbCrePten(flox/flox) mice showed massive hepatomegaly and steatohepatitis with triglyceride accumulation, a phenotype similar to human nonalcoholic steatohepatitis.
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