Racial Biofutures: COVID-19 and Black Futurity Otherwise.

Through a consideration of COVID-19, this article offers a series of provocations in thinking about racial biofutures. First, it suggests that looking backwards through a lens of recursivity only allows us to see the same anti-black futures mapped out again and again, the repeated production of predictable futures - always - already precarious. Second, along with many others, I argue that we this story of recursivity and that naming these repetitions is analytically reductive and politically deficient: this is a .

Abject Ontologies: Cancer and 'Living On'.

This paper examines cancer through the lens of abjection. While cancer can be understood as an abject lifeform, we explore what we name the abject ontologies created through both cancer detection technologies/practices and cancer treatment, specifically the drug combination Adriamycin and Cytoxan. We ask: what are the abject ontologies produced through living with and living on from cancer diagnosis and treatment? Our concern is to map how cancer undoes our supposedly stable categories inherited from modernist logic, challenges our very ideas of what it means to be human, and demands an ethical reorientation of public cancer discourse.

Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease.

Background: Congenital heart disease (CHD) occurs in almost 1% of newborn children and is considered a multifactorial disorder. CHD may segregate in families due to significant contribution of genetic factors in the disease etiology. The aim of the study was to identify pathophysiological mechanisms in families segregating CHD.

The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells.

Background: Resistance to taxane-based therapy in breast cancer patients is a major clinical problem that may be addressed through insight of the genomic alterations leading to taxane resistance in breast cancer cells. In the current study we used whole exome sequencing to discover somatic genomic alterations, evolving across evolutionary stages during the acquisition of docetaxel resistance in breast cancer cell lines.

Results: Two human breast cancer in vitro models (MCF-7 and MDA-MB-231) of the step-wise acquisition of docetaxel resistance were developed by exposing cells to 18 gradually increasing concentrations of docetaxel.

Tear film proteins deposited on high water content contact lenses identified with two-dimensional gel electrophoresis and mass spectrometry.

Purpose: Tear film proteins adhere to the surface of contact lenses (CLs). While the proteins in the tears have been extensively studied with various proteomic techniques, adhered proteins to CLs are less studied. In this pilot study, we have separated proteins with 2D gel electrophoresis prior to the conventional mass spectrometry (MS) in order to analyse the deposited proteins on hydrogel CLs from myopic patients.

Risking 'Safety': Breast Cancer, Prognosis, and the Strategic Enterprise of Life.

Living in modern biopolitical risk culture might be seen as synonymous with living in prognosis time, in the sense that risk of illness is endlessly forecast (prognosticated) in the broad social arena. 'Safety,' in this context, is framed as the anticipatory guarding against risk or disease in order to 'make live.' Thinking of risk and safety in these ways is limited, however, in that the prognosis cannot account for the individual's life or death drama.

Clinical results of 40 years of paediatric keratoplasty in a single university eye clinic.

Purpose:   To evaluate indications for paediatric keratoplasty in recipients aged ≤16 years and assess long-term clinical outcome.

Method:   Recipients were identified from records of the Danish Cornea Bank. Data were collected from patient journals, clinical follow-up examinations and questionnaires and stratified into pre-, peri- and postoperative variables.

Metabolic profile of keratoconic cornea.

Purpose: To investigate the difference in metabolic profile of keratoconic and normal corneas using two different analysis methods.

Methods: Keratoconic corneas were obtained from patients (aged 19-27) during transplantation surgery. Control samples were obtained from human donors (aged 61-75) 1-8 h post-mortem.

History of Acta Ophthalmologica - the first 50 years.

Acta Ophthalmologica appeared as the scientific journal of the Nordic ophthalmological Societies in 1923. The intention was to expose the clinical and experimental developments among the ophthalmological communities of the four Nordic countries: Denmark, Finland, Norway and Sweden. The collaboration within the field of ophthalmology had been attempted with the publication of 'Nordisk ophthalmologisk Tidsskrift' in the years 1889-1892.

Impact of organ culturing on metabolic profile of human corneas: preliminary results.

Purpose: It is suggested that the quality of corneal graft may depend on modifications that appear in the tissue during culturing. The aim of this study was to investigate the differences in the metabolic profile between cultured and noncultured human corneas.

Methods: Corneas from 12 donors were obtained post-mortem and cultured for 6-20 days.

Nordisk ophthalmologisk tidsskrift 1889-1892: the Nordic Journal of Ophthalmology - a forerunner of Acta Ophthalmologica.

In the second half of the nineteenth century several ophthalmological journals appeared (Germany, England, France, United States). In the northern countries (Denmark, Finland, Norway, Sweden) an initiative lead to 'Nordisk ophthalmologisk Tidsskrift' published in the scandinavian languages in the years 1889-92. The 'driving force' behind the journal was the first professor in Ophthalmology in Copenhagen, Dr.

Attempting to distinguish between endogenous and contaminating cytokeratins in a corneal proteomic study.

Background: The observation of cytokeratins (CK's) in mass spectrometry based studies raises the question of whether the identified CK is a true endogenous protein from the sample or simply represents a contaminant. This issue is especially important in proteomic studies of the corneal epithelium where several CK's have previously been reported to mark the stages of differentiation from corneal epithelial stem cell to the differentiated cell.

Methods: Here we describe a method to distinguish very likely endogenous from uncertain endogenous CK's in a mass spectrometry based proteomic study.

Morphological evaluation of normal human corneal epithelium.

Purpose: The human corneal epithelium is usually described as a 50-μm-thick layer of regular stratified squamous non-keratinized cells with a thickness of 5-7 cells. The purpose of this study is systemically to revisit the histopathological appearance of 100 corneas.

Methods: 5-μm-thick sections of corneas from 100 consecutively selected paraffin-embedded eyes were stained with hematoxylin-eosin and Periodic Acid-Schiff (PAS).

Precision and accuracy of the ICare tonometer - Peripheral and central IOP measurements by rebound tonometry.

Purpose: The purpose of this study was to evaluate the ICare tonometers precision and accuracy and the extent to which intraocular pressure (IOP) measurements are influenced by measuring position.

Methods: This was carried out by comparing the central and peripheral ICare-IOP readings and comparing ICare- with the Goldmann applanation tonometer (GAT)-IOP readings. IOP was measured using the ICare rebound tonometer on the right eye of 40 subjects, straight at the centre of the cornea (CS), straight 2 mm from the nasal and temporal limbus (NS and TS), and in 10 degrees nasally and temporally angled positions measured from the same location as CS (NA and TA).

Influence of suture regularity on corneal astigmatism after penetrating keratoplasty.

Purpose: To investigate whether suture regularity affects corneal astigmatism after keratoplasty.

Methods: Twenty-one patients undergoing penetrating keratoplasty for various corneal diseases were included in the study. The grafts were sutured in place using a single-running Nylon 10-0 suture, taking 24 bites.

Riboflavin-UVA treatment in the management of edema and nonhealing ulcers of the cornea.

Purpose: Riboflavin-ultraviolet A (UVA) treatment induces cross-linking and stiffens the corneal stroma. A parallel reduction in stromal swelling and increased resistance to microbial and enzymatic degradation has been suggested. The purpose of this study was to evaluate the potential of riboflavin-UVA treatment in the management of corneal disorders, in particular edema due to endothelial decompensation and non-healing ulcers.

Longterm follow-up of penetrating keratoplasty for keratoconus.

Purpose: This study aims to describe the current visual and refractive status of patients who underwent penetrating keratoplasty (PK) for keratoconus > 20 years ago and to report on the current status of their grafts.

Methods: A total of 138 eyes in 103 patients were grafted for keratoconus between August 1968 and December 1985. Patients who had not undergone retransplantation were invited to attend a clinical examination.

Corneal grafting and banking.

Corneal transplantation was conceptualized at the end of the 18th century, but it took more than 100 years before human corneal grafting was introduced. The greatest step forward was the demonstration by Filatov that corneal tissue can be collected and used post mortem. The history of eye banking includes the development of preservation techniques.

Descemet's stripping automated endothelial keratoplasty and penetrating keratoplasty for Fuchs' endothelial dystrophy.

Purpose: To compare the outcome of Descemet's stripping endothelial keratoplasty (DSAEK) to that of penetrating keratoplasty (PK) in patients with Fuchs' endothelial dystrophy.

Methods: The first 20 patients who underwent DSAEK at the Department of Ophthalmology, Aarhus University Hospital were compared to 20 patients treated with classic PK. Best-corrected visual acuity, subjective spectacle refraction and corneal thickness were registered before surgery and 1, 3, 6 and 12 months after DSAEK surgery; they were also measured before surgery and 12 months and 2-3 years after PK.

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation.

Objective: The maintenance of pluripotency of human embryonic stem cells (hESCs) requires a high efficiency of self-renewal. During in vitro propagation, however, hESCs have a propensity to differentiate spontaneously. In this study, we assessed the nature of hESC responses to hypoxic conditions.

Comparison of two partial coherence interferometers for corneal pachymetry in high myopia and after LASIK.

Purpose: We aimed to compare the Haag-Streit optical low-coherence reflectometry (OLCR) pachymeter and the Zeiss Anterior Chamber Master (ACMaster) for measuring central corneal thickness (CCT) in high myopes and after laser in situ keratomileusis (LASIK) for myopia.

Methods: Central corneal thickness was measured in 55 eyes of 30 myopic subjects (spherical equivalent refraction of - 5.25 D to - 10.

Immunohistochemical markers for corneal stem cells in the early developing human eye.

The corneal epithelium is continuously being renewed. Differentiated epithelial cells originate from limbal stem cells (LSCs) located in the periphery of the cornea, the corneoscleral limbus. We have recently identified superoxide dismutase 2 (SOD2) and cytokeratin (CK) 15 as limbal basal cell markers and potential markers for LSCs and early transient amplifying cells in human adults.