Antimalarial Susceptibility of and Isolates to Selected Antimalarial Agents, Column Chromatographic Subfractions of Leaves Extract and FTIR and GCMS of SF8.

Malaria still remains a life-threatening parasitic disease with universal targets set for control and elimination. This study aimed to evaluate the antimalarial susceptibility of isolates and to selected antimalarial agents and column chromatographic subfractions of leaves extract and FTIR and GCMS of SF8. Trager and Jensen as well as World Health Organisation (WHO) standardised micro-test system methods were used to determine susceptibility on the patients' blood samples; Column chromatographic procedure was carried out to obtain 11 pooled fractions; FTIR and GCMS were used to determine functional groups and phytochemicals respectively.

Phenotypic and genotypic characterization of clinical carbapenem-resistant isolates from Sokoto, northwest Nigeria.

Emergence and spread of carbapenemase-producing (CPE) are two of the major problems currently threatening global public health. In Nigeria, interest in CPE is recent. In Sokoto, northwest Nigeria, there are no data on the prevalence and mechanism underlying carbapenem resistance.

First whole genome sequence of Paenalcaligenes suwonensis bearing bla Metallo-β-lactamase: A clinical isolate responsible for acute gastroenteritis.

Carbapenemase-producing Alcaligenes species has been described in only few studies, with none so far from the African continent. Here, we report the whole genome sequence of Peanalcaligenes suwonensis bearing bla metallo-β-lactamase and first detection of carbapenemase producing Alcaligenes faecalis isolated from patients attending tertiary healthcare facilities in Nigeria. The isolates were identified by MALDI-TOF Mass Spectrometry.

Epidemiology of surgical site infections in Nigeria: A systematic review and meta-analysis.

Introduction: Surgical site infection (SSI) is a major patient safety concern in hospitals. Unlike most developed countries, Nigeria does not yet have an established national system to monitor the occurrence of this infection. This meta-analysis was thus designed to determine the pooled cumulative incidence of SSIs and various determinants of its occurrence in Nigeria.

A Novel Methicillin-Resistant t11469 and a Poultry Endemic Strain t002 (ST5) Are Present in Chicken in Ebonyi State, Nigeria.

Background: The changing epidemiology of methicillin-resistant (MRSA) from a hospital-associated pathogen to an organism commonly found in the community and in livestock reflects an organism well-equipped to survive in diverse environments and adjust to different environmental conditions including antimicrobial use.

Methods: We investigated the molecular epidemiology of and MRSA in poultry in Ebonyi State, Nigeria. Samples were collected from 1800 birds on 9 different farms within the state.

Evaluation of the antibacterial and antidiarrhoeal activities of heeria insignis o. Ktze.

Heeria insignis O. Ktze (Anacardiaceae) is an indigenous African shrub used in treatment of diarrhea, venereal diseases, tapeworm, hookworm, schistosomiasis, kidney trouble and for increasing lactation in women after childbirth. The methanol and dichloromethane extracts of the leaves were evaluated for antibacterial activity (using agar-diffusion method) and antidairrheal activity (using isolated rabbit jejunum and castor-oil induced diarrhea in mice).

Synthesis and Antifungal Activity of Some Organotin(IV) Carboxylates.

Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth.

Antibiotic sensitivity profiles of salmonella organisms isolated from presumptive typhoid patients in Zaria, northern Nigeria.

A hundred and ten Salmonella organisms (comprising 38 Salm. typhi, 13 Salm. paratyphi and 59 non-typhi Salmonella spp.

Phytochemical and antimicrobial activities of the Daniellia oliveri leaves.

The n-butanol soluble part and four chromatographic fractions of the aqueous ethanolic extract of the leaves of Daniellia oliveri were investigated for antimicrobial properties. All fractions showed activity against Staphylococcus aureus. A chromatographic fraction showed significant activity against the fungus Tricophyton rubrum.

Antifungal activity of n-tributyltin acetate against some common yam rot fungi.

The antifungal activity of n-tributyltin acetate (TBTA) was examined in relation to combating yam rot disease. TBTA exhibited a significant effect in vitro and in vivo on four yam rot fungal isolates tested. However, the in vitro toxicity of TBTA was drastically reduced when 2.