Publications by authors named "Egy Rahman Firdaus"
Merozoite surface protein 1 paralog is involved in the human erythrocyte invasion of a zoonotic malaria, .
Front Cell Infect Microbiol
December 2023
The zoonotic malaria parasite is an important public health concern in Southeast Asia. Invasion of host erythrocytes is essential for parasite growth, and thus, understanding the repertoire of parasite proteins that enable this process is vital for identifying vaccine candidates and how some species are able to cause zoonotic infection. Merozoite surface protein 1 (MSP1) is found in all malaria parasite species and is perhaps the most well-studied as a potential vaccine candidate.
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- The computer vision diagnostic approach is improving malaria testing tools, making them easier to use in clinics in malaria-prone areas.
- The new malaria scanner tool effectively detects live malaria parasites with better precision than traditional microscopy, aligning closely with fluorescence-activated cell sorting (FACS) analysis.
- While the new tool shows strong correlation in measuring parasitemia levels, it still requires improvements in distinguishing between different malaria species.
Plasmodium vivax reemerged in 1993. It has been sustained for more than 25 years and become one of the important indigenous parasitic diseases in northern and western parts of the Republic of Korea near the demilitarized zone. In particular, relapse is a significant concern for the control of malaria, as short- and long-term incubation periods vary among those infected in Korea.
View Article and Find Full Text PDFMalaria is caused by multiple different species of protozoan parasites, and interventions in the pre-elimination phase can lead to drastic changes in the proportion of each species causing malaria. In endemic areas, cross-reactivity may play an important role in the protection and blocking transmission. Thus, successful control of one species could lead to an increase in other parasite species.
View Article and Find Full Text PDFToxoplasma gondii is an apicomplexan parasite that causes toxoplasmosis in the human body and commonly infects warm-blooded organisms. Pathophysiology of its diseases is still an interesting issue to be studied since T gondii can infect nearly all nucleated cells. Imaging techniques are crucial for studying its pathophysiology.
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- Malaria invasion into red blood cells is a fast process governed by specific ligand-receptor interactions, posing challenges for developing effective vaccines targeting Plasmodium knowlesi.
- This study tested pre-clinical vaccine candidates by creating an in vitro invasion inhibition assay with P. knowlesi, focusing on the Duffy binding protein alpha (PkDBPα) and apical membrane antigen 1 (PkAMA1) proteins.
- The research found that antibodies against PkDBPα and PkAMA1 significantly inhibited the growth of the malaria parasite and showed that these proteins are prevalent in human patients, supporting their potential for vaccine development.