Publications by authors named "Egharevba Godshelp Osas"
Molecular docking, pharmacophore modelling, MD simulation and ADMET study reveals bitter cola constituents as potential inhibitors of SARS-CoV-2 main protease and RNA dependent-RNA polymerase.
J Biomol Struct Dyn
March 2023
A mini survey was employed in the search of herbs and spices which people believe could prevent them from contracting COVID-19. Phytochemicals which have been earlier implicated for the bioactivity of the afore-mentioned herbs and spices were identified through literature search. The phytochemicals were then subjected to pharmacore modelling, molecular docking and molecular dynamics simulation in order to identify phytochemicals that could serve as inhibitors of 3-Chymotryprin-like protease and RNA dependent-RNA polymerase of SARS-CoV-2.
View Article and Find Full Text PDFAntimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae).
Pak J Pharm Sci
March 2021
Article Synopsis
- Epidemiological studies highlight the importance of fruits and vegetables for health; however, drug-resistant bacteria are becoming a significant concern, leading to increased mortality.
- A flavonoid called Catechin-3-o-rhamnoside was isolated from Lannea kerstingii using dry vacuum liquid chromatography and characterized with various NMR techniques.
- The compound demonstrated strong antimicrobial activity against several resistant bacteria and fungi, along with high antioxidant activity, suggesting its potential as a natural remedy for drug-resistant infections.
Aims: Plant extracts have long been used for the ethnomedical treatment of diabetes, microbial infections and as a source of antioxidant. This study was aimed at investigating the antidiabetic, antioxidant, and antimicrobial activities of the n-hexane and ethyl acetate extract of leaves (TBL) as associated with the ethnobotanical knowledge of the local people of Nigeria.
Main Methods: The phytochemical composition of the n-hexane and ethyl acetate extract of the leaves of were determined following standard procedures in literature, and it's inhibitory activities against α-glucosidase enzyme.