Half-Sandwich Arene Ruthenium(II) Thiosemicarbazone Complexes: Evaluation of Anticancer Effect on Primary and Metastatic Ovarian Cancer Cell Lines.

In this study, we describe the synthesis, characterization and antiproliferative activity of three organo-ruthenium(II) half-sandwich complexes [RuCl(η--cym)(-L)]Cl (I, II, and III). To form these complexes, three thiosemicarbazone ligands (TSCs) were synthesized; L = 5-nitro-2-carboxyaldehyde-thiophen--methyl-thiosemicarbazone, (L1); 2-acetyl-5-bromo-thiophen--methyl-thiosemicarbazone, (L2) and 2-acetyl-5-bromo-thiophen--dimethyl-thiosemicarbazone, (L3). The isolated compounds were analyzed using spectroscopic techniques such as elemental analysis, conductance measurements, FT-IR, H NMR spectroscopy, MALDI-TOF mass spectrometry, and single-crystal XRD.