Publications by authors named "Efthymia Kallistrou"
Critical illness (CI) triggers complex disruptions in the growth hormone (GH)/insulin-like growth factor (IGF) axis, significantly affecting the dynamics of insulin-like growth-factor-binding proteins (IGFBPs). Among these, IGFBP-2 shows a sustained elevation during CI, which inversely correlates with serum levels of IGF-1, IGFBP-3, and the acid-labile subunit (ALS). Although IGFBP-2 does not directly interact with ALS, it may influence the availability of IGFs by competing with other IGFBPs for binding to IGF-1 and IGF-2.
View Article and Find Full Text PDFThis review delved into the intricate relationship between circadian clocks and physiological processes, emphasizing their critical role in maintaining homeostasis. Orchestrated by interlocked clock genes, the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle, energy metabolism, immune function, and cell proliferation. The central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral tissue clocks are influenced by cues such as feeding times.
View Article and Find Full Text PDFArticle Synopsis
- Normal anion gap hyperchloremic acidosis with hypokalemia is a serious medical condition, and distal renal tubular acidosis is one of its rare causes.
- A previously healthy woman was admitted with severe muscle weakness and was found to have low potassium levels, high chloride levels, and low bicarbonate levels, indicating non-gap metabolic acidosis.
- She quickly improved with electrolyte replacement therapy, showcasing that distal renal tubular acidosis can occur temporarily even in otherwise healthy patients.