Publications by authors named "Efstathia Polychronopolou"
Article Synopsis
- The study investigates the relationship between statins, testosterone replacement therapy (TTh), and cardiovascular disease (CVD) among men, comparing those with hormone-related cancers (HRCa) to cancer-free individuals.
- A large sample of 44,330 men was analyzed, revealing that both statins and TTh were independently linked to a lower incidence of CVD, especially when used together, although TTh alone didn't show the same effect for HRCa survivors.
- The findings suggest that pre-diagnostic use of statins and TTh reduces the risk of CVD, warranting further investigation into specific cardiovascular outcomes for those with a history of hormone-related cancers.
Aims: This study aimed to investigate the association of testosterone replacement therapy (TTh) with risk of cardiovascular disease (CVD), and CVD-specific outcomes, in cisgender women and transgender population, and to determine whether this association varies by menopausal status.
Methods: In 25 796 cisgender women and 1580 transgender people (≥30 years old) who were enrolled in the Optum's deidentified Clinformatics Data Mart Database (2007-2021), we identified 6288 pre- and postmenopausal cisgender women and 262 transgender people diagnosed with incident composite of CVD (coronary artery disease [CAD], congestive heart failure, stroke, and myocardial infarction). Prediagnostic prescription of TTh was ascertained for this analysis.