Publications by authors named "Efren Alvidrez"
Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism.
Mayra A Gonzalez Idaly M Olivas Alfonso E Bencomo-Alvarez Andres J Rubio Christian Barreto-Vargas Efren Alvidrez
Clin Transl Med
December 2022
Article Synopsis
- Tyrosine kinase inhibitors (TKIs) have transformed chronic myeloid leukaemia (CML) from a deadly condition into a manageable one, but drug-resistant leukaemia stem cells present a significant challenge for achieving a cure.
- A new study highlights the downregulation of the G0/G1 switch gene 2 (G0S2), a key regulator of lipid metabolism, in various instances of TKI resistance, which correlates with poorer survival outcomes for patients.
- The research indicates that the decrease in G0S2 is influenced by transcriptional repression from MYC rather than by genetic changes or BCR::ABL1 activity, suggesting that restoring G0S2 could be crucial for improving treatment responses
Detection of Anticancer Drug-Induced Cardiotoxicity Using VCAM1-Targeted Nanoprobes.
ACS Appl Mater Interfaces
August 2022
Chemotherapy-induced cardiac toxicity is an undesirable yet very common effect that increases the risk of death and reduce the quality of life of individuals undergoing chemotherapy. However, no feasible methods and techniques are available to monitor and detect the degree of cardiotoxicity at an early stage. Therefore, in this project, we aim to develop a fluorescent nanoprobe to image the toxicity within the cardiac tissue induced by an anticancer drug.
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