Publications by authors named "Efrain J Perez-Lao"
Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia. There is currently no effective treatment for VCID. Resveratrol (RSV) is considered an antioxidant; however, our group has observed pleiotropic effects in stroke paradigms, suggesting more effects may contribute to mechanistic changes beyond antioxidative properties.
View Article and Find Full Text PDFArticle Synopsis
- Cardiac arrest survivors often face long-term cognitive impairments, and physical exercise may help improve cognitive functions in these cases.
- A study found that physical exercise after cardiac arrest preserved memory in rats but did not prevent the death of hippocampal cells, while it did reduce cell death in the septal and thalamic regions.
- The research also indicated that exercise post-cardiac arrest influenced gene expression related to neuroinflammation, plasticity, and cell death, highlighting its neuroprotective mechanisms for cognitive function.
Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an NAD -dependent manner. The mammalian family of sirtuins is composed of seven histone deacetylase and ADP-ribosyltransferase proteins (SIRT1-SIRT7) that are found throughout the different cellular compartments of the cell. Sirtuins in the brain have received considerable attention in cognition due to their role in a plethora of metabolic and age-related diseases and their ability to induce neuroprotection.
View Article and Find Full Text PDF