[Psychological characteristics of working and non-working elderly people.].

A comparative analysis of the psychological characteristics of the working and non-working population in the context of personal employment, demand and quality life. The study was conducted with the participation of 51 women and 58 men, age 65,35±5,25 years. Randomization into two groups: the 1st group - 59 people of those continuing to work in the field of higher and vocational education; the 2nd group (50 people) consisted of non-working pensioners whose labor activity was related to teaching, taking care of their families, children and grandchildren, the circle of their social contacts is limited by the connections necessary to ensure life.

[The assessment of risk factors of development of extra body mass in children of school age].

The global problems of children health include overweight and obesity and associated high risks of disability, premature death and complications of mental health in adult age. Purpose of the study is to identify alimentary and social risk factors of development of extra body mass in children and adolescents 7-17 years old residing in industrial center of the Eastern Siberia. The average age of studied group of children was 10.

CLASP2 facilitates dynamic actin filament organization along the microtubule lattice.

Coordination between the microtubule and actin networks is essential for cell motility, neuronal growth cone guidance, and wound healing. Members of the CLASP (cytoplasmic linker-associated protein) family of proteins have been implicated in the cytoskeletal cross-talk between microtubules and actin networks; however, the molecular mechanisms underlying the role of CLASP in cytoskeletal coordination are unclear. Here, we investigate CLASP2α's cross-linking function with microtubules and F-actin.

Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity.

The formation and recovery of gaps in the vascular endothelium governs a wide range of physiological and pathological phenomena, from angiogenesis to tumor cell extravasation. However, the interplay between the mechanical and signaling processes that drive dynamic behavior in vascular endothelial cells is not well understood. In this study, we propose a chemo-mechanical model to investigate the regulation of endothelial junctions as dependent on the feedback between actomyosin contractility, VE-cadherin bond turnover, and actin polymerization, which mediate the forces exerted on the cell-cell interface.

[Risk assessment for public health associated with nitrate content in crop products].

The increasing need of the population for crop products (СP) makes continuous monitoring of nitrate content an increasingly urgent task. The accumulation of multidirectional data on the effect of nitrates on the state of the body requires further studies to assess the alimentary risk caused by their admission to the population of various regions. of the work was to study the levels of nitrate contamination of CP and assess the associated risk to the health of children and adults in the Baikal Region.

Uptake of Radionuclides Co, Cs, and Sr with α-FeO and FeO Particles from Aqueous Environment.

In the paper, investigation results of the uptake efficiency of radionuclides Co, Sr, and Cs dissolved in water onto iron oxides α-FeO and FeO are presented. It was found that sorption efficiency increased for higher pH values. Independent of the oxide nature, the uptake characteristics are the best toward Co and the worst toward Cs, forming the row as follows: Co > Sr > Cs.

Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion.

Cell migration is driven by pushing and pulling activities of the actin cytoskeleton, but migration directionality is largely controlled by microtubules. This function of microtubules is especially critical for neuron navigation. However, the underlying mechanisms are poorly understood.

Characterization of Nanoscale Organization of F-Actin in Morphologically Distinct Dendritic Spines Using Supervised Learning.

The cytoarchitecture of a neuron is very important in defining morphology and ultrastructure. Although there is a wealth of information on the molecular components that make and regulate these ultrastructures, there is a dearth of understanding of how these changes occur or how they affect neurons in health and disease. Recent advances in nanoscale imaging which resolve cellular structures at the scale of tens of nanometers below the limit of diffraction enable us to understand these structures in fine detail.

[Features of actual nutrition of the adult population in Republic of Buryatia in modern conditions].

Evaluation of the actual nutrition of the population of individual regions allows the development of targeted practical measures to improve nutrition, the structure of food consumption and appropriate recommendations to ensure optimal development and health status of a person. In order to study the nutrition of the adult population of the Republic of Buryatia, a retrospective analysis of the feeding structure data was conducted according to the data of the territorial department of the Federal State Statistics Service for the Republic of Buryatia, and the results obtained in the course of the questionnaire survey of 426 people (chosen by selective method with observance of representativeness) were analyzed. The data are presented obtained on the results of comparison with physiological needs in energy and nutrients for men and women in the most employable age of 30-39 years, having the third group of labor intensity.

Branched actin networks push against each other at adherens junctions to maintain cell-cell adhesion.

Adherens junctions (AJs) are mechanosensitive cadherin-based intercellular adhesions that interact with the actin cytoskeleton and carry most of the mechanical load at cell-cell junctions. Both Arp2/3 complex-dependent actin polymerization generating pushing force and nonmuscle myosin II (NMII)-dependent contraction producing pulling force are necessary for AJ morphogenesis. Which actin system directly interacts with AJs is unknown.

Blazar spectral variability as explained by a twisted inhomogeneous jet.

Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancement and contraction of the variability timescales, so that most blazars appear as luminous sources characterized by noticeable and fast changes in brightness at all frequencies.

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation.

Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their widening. Here, by conducting high-resolution microscopy approaches we unveil the presence of an actomyosin cable encircling TEMs.

βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons.

Dendritic spines are postsynaptic structures in neurons often having a mushroom-like shape. Physiological significance and cytoskeletal mechanisms that maintain this shape are poorly understood. The spectrin-based membrane skeleton maintains the biconcave shape of erythrocytes, but whether spectrins also determine the shape of nonerythroid cells is less clear.

A minimal actomyosin-based model predicts the dynamics of filopodia on neuronal dendrites.

Dendritic filopodia are actin-filled dynamic subcellular structures that sprout on neuronal dendrites during neurogenesis. The exploratory motion of the filopodia is crucial for synaptogenesis, but the underlying mechanisms are poorly understood. To study filopodial motility, we collected and analyzed image data on filopodia in cultured rat hippocampal neurons.

[Current Possibilities of Using Radiopharmaceuticals to Evaluate Cerebral Blood Flow].

A comparison of the possibilities of using various neurotropic radiopharmaceuticals for scintigraphic evaluation of cerebral perfusion. In the whole range of radiopharmaceuticals used to diagnose cerebral blood flow disorders, there are Ceretec (99mTc-hexamethylpropyleneamine) and Neurolite (N,N-1,2-ethylenediylbis-L-cysteine-diethyl ether), which are the most optimal agents. Due to their high cost and related radiation exposure, the radiopharmaceuticals 123І-IMP (123I-isopropyl-iodoamphetamine) and 201Tl-DDC (diethyldithiocarbamate) labeled with thallium-201 virtually minimize the possibilities of being used in daily clinical practice.

Neurite outgrowth is driven by actin polymerization even in the presence of actin polymerization inhibitors.

Actin polymerization is a universal mechanism to drive plasma membrane protrusion in motile cells. One apparent exception to this rule is continuing, or even accelerated outgrowth of neuronal processes in the presence of actin polymerization inhibitors. This fact together with a key role of microtubule dynamics in neurite outgrowth led to the concept that microtubules directly drive plasma membrane protrusion, either in the course of polymerization or motor-driven sliding.

[REGIONAL INDICES OF TRACE ELEMENT LEVELS IN HAIR IN CHLILDREN OF THE POPULATION OF THE IRKUTSK REGION].

747 hair samples of the pre-school aged children from different regions of the Irkutsk Region have been analyzed with the aim to establish the regional reference indices. The measurements were performed by the atomic-absorption method. The population deficiency of the essential microelements of zinc, copper along with the simultaneous excess of magnesium, mercury was revealed to be observed at the territory of the Irkutsk Region.

Podosome dynamics and location in vascular smooth muscle cells require CLASP-dependent microtubule bending.

Extracellular matrix (ECM) remodeling during physiological processes is mediated by invasive protrusions called podosomes. Positioning and dynamics of podosomes define the extent of ECM degradation. Microtubules are known to be involved in podosome regulation, but the role of microtubule (MT) network configuration in podosome dynamics and positioning is not well understood.

[THE LEVELS OF SPECIFIC AUTOANTIBODIES AND RISKS FOR THE FORMATION OF PATHOLOGICAL PROCESSES IN CONDITIONS OF INHALATION EXPOSURE TO CHEMICALS].

The exposure of atmospheric pollutants on the organism may be a precondition for the development of pathological processes in organs and system to which they have tropicity. The change in the levels of specific autoantibodies occur long before the clinical manifestation of the disease. The aim of the study was the investigation of relationships between the levels of specific autoantibodies and risks of the formation of pathological processes of organs and systems in conditions of the inhalation exposure to chemicals.

[Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment].

The article presents results of study of the impact of iodine deficiency and technogenic fluoride on the state of the thyroid gland in children. On the example of two districts of the city of Bratsk there were executed dynamic investigations (2002 and 2012), including the estimation of the pollution of ambient air and soil by fluorine compounds, levels of iodine intake by the body, the clinical examination of children aged from 5 to 7 years d and interviewing of their parents. In the course of the medical examination there were executed: physical examination by the pediatrician, endocrinologist, ultrasound examination of the thyroid gland, the determination both of serum hormone content by radioimmunoassay and urinary excretion offluorine and iodine.

[Assessment of carcinogenic risks to workers of the main enterprises of the Irkutsk region].

The purpose of research is the assessment of the individual cancer risk (ICR) for workers of the basic occupations in key branches of industry of the Irkutsk region. There was executed the calculation of ICR levels for workers of the basic occupations of the aircraft industry, aluminum smelters and vinyl chloride production plants. The estimation of the exposure for workers was carried out according to long-term time-weighted average concentrations in the air of the working area, for the population - on annual average concentrations in the ambient air.

[Hygienic estimation of the nutrition and the risk of morbidity associated with its violation].

Among risk factors possessing a main importance in the shaping of theA public health the leading place is featured to the rational nutrition. Presented results testify to the absence of stable group in the adult population of Irkutsk who eats regularly, with a rational multiplicity and having all essential meal reception and the recommended food package. There was revealed the role of nutrition in shaping of morbidity rate in the adult population.

[Individual risks to adolescent health, caused by contaminating the air, and their relationship with the levels of specific autoantibodies].

The high levels of the air pollution create prerequisites for the development of the pathology of target organs exposed to chemical agents. Big enterprises of oil refining and chemical industry of the Irkutsk region are located in the cities of Angarsk and Sayansk. The average level of the air pollution for several years in these cities is assessed as high and moderate, respectively.

[Hygienic assessment of the overwroughtness of educational activity in schoolchildren of 5-10 classes of secondary schools].

The state of health in children and adolescents during the time of education in secondary schools is getting worse: the prevalence rate of functional disorders and chronic diseases is increasing. There was executed the assessment of the overwroughtness of the training-education process in secondary school institutions. The prior characteristics of the educational activity are: intellectual, sensory, emotional loads; their monotony and mode of educational activity, school work intensity.

[Changes in Cerebral Blood Flow and Cognitive Function in Patients Undergoing Coronary Bypass Surgery With Cardiopulmonary Bypass].

Purpose: to study effect of coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) on regional cerebral blood flow and cognitive function in patients with ischemic heart disease (IHD).

Material And Methods: We included into this study 22 patients with IHD subjected to CABG surgery with CPB. All patients underwent brain SPECT scanning and comprehensive neuropsychological testing 1 day before, 10-14 days and 6 months after surgery.