[High-tone therapy in complex rehabilitation of patients with post-sternotomy syndrome after coronary artery bypass surgery. (Open-label, prospective, randomized controlled trial)].

Introduction: At present it remains relevant to develop new rehabilitation technologies for patients with circulatory system diseases who have undergone a cardiac surgery to restore the functions of the cardiorespiratory system more quickly, improve physical and mental health, and prevent the development of the atherosclerotic process.

Aim: To study the effectiveness and safety of the new rehabilitation technology for the inpatient stage of medical rehabilitation of patients with post-sternotomy syndrome after coronary artery bypass surgery (CABS) using high-tone therapy.

Material And Methods: The study included 85 men (the average age was 56.

[Physical factors in the medical rehabilitation of patients with chronic cerebral ischemia in the outpatient stage].

Unlabelled: Chronic cerebral ischemia is an urgent problem of modern medicine due to high disability of this contingent of patients and requires new approaches to the treatment and medical rehabilitation.

Objective: To develop a new technology for medical rehabilitation of the patients with chronic cerebral ischemia on an outpatient basis using therapeutic physical factors (such as ozone therapy and magnetic field in combination with endomassage) against the background of rational pharmacotherapy and psychocorrection.

Material And Methods: There have been observed 122 patients with chronic cerebral ischemia stage I.

[Natural therapeutic factors in medical rehabilitation of patients with post-COVID syndrome].

Unlabelled: The feasibility of using therapeutic physical factors in post-COVID syndrome is due to their sanogenetic effects that ensure the restoration of impaired bodily functions, which serves as the basis for their use at various stages of medical rehabilitation of this category of patients.

Objective: To develop a new medical technology for the 3 outpatient stage of medical rehabilitation of the patients with post-COVID syndrome using natural therapeutic factors of Nalchik resort.

Material And Methods: There has been carried out a controlled study in compliance with the principles of randomization to develop an outpatient medical rehabilitation program including 168 patients with post-COVID syndrome.

[EXPERIMENTAL JUSTIFICATION OF CORRECTIVE ACTION OF NATIVE AND SELENIUM-MODIFIED MINERAL WATERS ON METABOLIC SYNDROME MODEL].

The purpose of the study was to determine the effect of native and selenium-modified mineral waters on metabolic syndrome models. Combined metabolic syndrome (combMS) was simulated in 70 white rats of male gender under standard vivarium conditions, using high-calorie food and single administration of streptozotocin. During the random sampling study the following groups of animals were formed: in the control group 1 (n=6) the rats had standard forage during the experiment; in the control group 2 (n=10) there were rats with combMS model without treatment; in the main groups, starting at the 61st day of combMS, the rats received: the 1st group (n=11) - Essentuki mineral water №4; the 2nd (n=16) - the same water with selenium; in the 3rd (n=11) - Slavyanovskaya mineral water; in the 4th (n=16) - Slavyanovskaya with selenium.

Nucleophile-Induced Rearrangement of 2-Azirine-2-carbonyl Azides to 2-(1-Tetrazol-1-yl)acetic Acid Derivatives.

2-Azirine-2-carbonyl azides undergo a rearrangement into derivatives of 2-(1-tetrazol-1-yl)acetic acid when interacting with O- and S-nucleophiles at room temperature. The reaction is catalyzed by tertiary amines or hydrazoic acid. The reaction with primary alcohols and phenols gives alkyl/aryl 2-(1-tetrazol-1-yl)acetates.

[Evaluation of the influence of different physical and chemical composition mineral waters on the state of carbohydrate metabolism in experimental metabolic syndrome].

Unlabelled: Purpose of the study. To carry out a comparative analysis of the intake effect of mineral waters (MW) of various physicochemical compositions, including those ones enriched in selenium, on the pathogenesis of metabolic syndrome (MS) in the experiment.

Materials And Methods: The experiment was carried out on 68 male white rats aged 3 months, which were divided into 5 groups.

[To the 100th anniversary of the founding of the Pyatigorsk research institute of balneology].

The article is dedicated to the 100th anniversary of the Pyatigorsk state research Institute of balneology. It presents the main stages of formation and development, scientific achievements of the Institute and highlights the main activities at the present stage.

Intra-atrial Neomitral Ring Creation in the Presence of Severe Mitral Annulus Calcification.

Severe mitral annulus calcifications significantly hinder surgical repair and replacement of the dysfunctional mitral valve. Herein, we present a novel surgical technique where we created an intra-atrial neomitral ring using a vascular Dacron graft in which a prosthetic valve was implanted. This approach is a simple alternative technique that can be used when anatomic prosthetic valve implantation is not feasible.

[The substantiation of the application of the high-intensity pulsed magnetic field for the combined treatment of biliary sludge].

Unlabelled: Despite the considerable achievements in the field of gastroenterology, there is still high incidence of diseases of the organs of the hepatobiliary system which necessitates the development of new therapeutic techniques for their management. Nowadays, high-intensity pulsed magnetic therapy is considered to be a highly efficacious method characterized by well-pronounced and many-sided action on the processes proceeding in the organism as a new preformed factor producing neurostimulatory, vasodilatory, trophic, and hypoalgesic effects. It appears to be effective with respect to biliary sludge (BS) since it can promote depletion of stagnant contents of the gall bladder and also intensify its contractile function.

[The role of the combined balneotherapeutic treatment as the 'add-back therapy' against the background of the anti-hormonal effects of the agonists of gonadotropin-releasing hormone in the women suffering from endometriosis genitalis externa].

Background: The use of agonists of gonadotropin-releasing hormone (GnRH) for the rehabilitation treatment of the patients presenting with endometriosis genitalis externa is known to significantly enhance the risk of development of hypoestrogenism. The so-called 'add-back-therapy' is carried out as a preventive measure to eliminate hypoestrogenism caused by the intake of GnRH agonists without detriment to the effectiveness of anti-hormonal therapy.

Aim: The objective of the present study was to estimate the effectiveness of the new method ('add-back hormone replacement therapy') in comparison with anti-hormonal therapy with the use of GRH agonists at the stage of the early postoperative medical rehabilitation based on the drinking of mineral waters (MW) and radon therapy (RT) in the patients who had undergone the laparoscopic interventions for the treatment of endometrioid heterotopies of the ovaries (1-3 months post-operatively).

[One-time effects of drinking mineral water and tap water enriched with silver nanoparticles on the biochemical markers of liver condition and metabolic parameters in healthy rats].

Aim:  The objective of the present research was to study the influence of tap water enriched with silver nanoparticles (NP) as well as that of «Krasnoarmeysky» and «Essentuki №17» mineral waters after their single administration through the oral gavage to the rats on the metabolism of carbohydrates and lipids, the biochemical markers of the liver condition, and the endocrine profile in the healthy animals.

Material And Methods:  The laboratory animals (130 male Wistar rats) were allocated to thirteen groups comprised of 10 rats each as follows: 1st group (n=10) intact animals, 2nd group (5 minutes after the administration of silver NP (n=10), 3rd group (15 minutes after the of silver NP), 4th group (60 minutes after the administration of silver NP), 5th group (n=10) (5 minutes after the introduction of the «Krasnoarmeysky» mineral water), 6th group (n=10) (15 min after the introduction of the «Krasnoarmeysky» mineral water), 7th group (n=10), (60 minutes after the introduction of the «Krasnoarmeysky» mineral water) 8th group (n=10) (5 minutes after the introduction of the «Essentuki № 17» mineral water), 9th group (n=10) (15 min after the introduction of the «Essentuki № 7» mineral water) , 10th group (n=10) (60 minutes after the introduction of the «Essentuki №17» mineral water), 11th group (n=10) (5 minutes after administration of tap water (control),12th group (n=10) (15 minutes after administration of tap water (control), and 13th (n=10) group 60 minutes after administration of tap water (control).

Results:  The study has demonstrated that the tap water enriched with silver nanoparticles similar to the mineral waters caused stress reactions that are inferior to those induced by «Essentuki №17» mineral water in terms of the magnitude; however, the effect provoked by the tap water was of longer duration.

[The spa and health resort-based treatment of metabolic syndrome with the application of the therapeutic courses of different duration: the evaluation according long-term results].

Aim: The objective of the present study was to estimate the effectiveness of the new therapeutic modalities for the spa and health resort-based treatment of metabolic syndrome based on the results of the long-term follow-up observations.

Material And Methods: A total of 100 patients presenting with metabolic syndrome were recruited for the participation in the study. All of them underwent a shortened course of mineral water intake in the combination with the use of the herbal medicinal products.

[URINE UNDER CHRONIC DYSFUNCTION OF RENAL ALLO-TRANSPLANT].

The study was organized to provide additional characteristic of chronic dysfunction of renal allo-transplant using such biomarkers of serum and urine as enzymes (alanine aminotransferase), aspartate aminotransferase, gamma- glutamiltransferase, alkaline phosphatase, N-acetyl-β-D-glucosaminidase, interleukins (IL-2, IL-8, IL-10), beta-2- microglobulin. The chronic dysfunction of renal allo-transplant is characterized by increasing of concentration of IL-10 and beta-2-microglobulin in serum and increasing of concentration of beta-2-microglobulin, IL-2, IL-8 in urine and increasing of activity of N-acetyl-β-D-glucosaminidase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamiltransferase as compared with patients with satisfactory function of renal allo-transplant. The multivariant logistic regression analysis established that only activity of N-acetyl-β-D-glucosaminidase in urine was reliably independently related to chronic dysfunction of renal allo-transplant.

[Scoring of severity of patients' condition with acute surgical diseases and injuries of the abdominal cavity].

Ten of the most frequent symptoms that do not require special methods of their determination except general clinical examinations established by any health care professional on pre-hospital stage were determined on the basis of analysis of more than one thousand records of patients with acute surgical abdominal diseases and clinical symptom load. The authors performed an assessment of each symptom depending on severity of patient's condition ranging from 1 point (satisfactory condition) till 5 points (critical condition). Information has been obtained: in case of satisfactory condition--up to 10 points, moderate--up to 20 points, heavy--up to 30 points, extremely heavy condition--up to 45 points and terminal condition--more than 45 points.

[The value of surgical experience gained during the Great Patriotic War for the modern military surgery].

The surgical experience gained during the Great Patriotic War (1941-1945) is a basis of the modern Russian military surgery, which allows providing any options for surgical care to the wounded. The article describes the main achievements of the military surgeons in our country during the Great Patriotic War, which helped the Soviet (Russian) military field surgery to achieve a leading position in the world of military medicine. The role of the united martial medical doctrine, three editions of "Guidelines for the military surgery", the qualified surgical assistance as a mean that helped to deliver surgical care to the wounded, the introduction of specialized medical care, technology development of medical triage, as well as the origins of the tactics of a multi-stage surgical treatment of combat trauma and special treatment of minimally wounded during the war.

[PIECETIME BURNS. SOURCES OF DANGER].

We analysed 54 foreign publications concerning sources of danger of thermal injuries inflicted in pieacetime. The negative effect of alcohol consumption is emphasised. Special attention is given to the necessity of safety measures when makingfire by people engaging in leisure activities and to the cases of chemical burns resulting from aggressive attacks of third persons.

[Surgical service at the Central Military Hospital of People's Commissariat of Defence shortly before the Great Patriotic War].

Authors present the article historical data on the foundation and development of surgical service at the 1st Therapeutic Red Cross Hospital (Central Military Hospital of People's Commissariat. of Defense) since its organization. The structure of the hospital surgical service and organization of surgical activity during the pre-war years is presented.

[The set of wearable medical equipment for medical and nursing teams].

The kit is designed in accordance with the list of the first medical aid procedures and syndromic standards of emergency medical care providing. The kit contains modern local hemostatic agents, vent tubes, cricothyrotomy, needles to eliminate pneumothorax, portable oxygen machine, sets for intravenous and intraosseous infusion therapy, collapsible plastic tires, anti-shock pelvic girdle, and other medical products and pharmaceuticals. As containers used backpack and trolley bag on wheels camouflage colours.

[The effectiveness of the spa and health resort-based treatment with the application of Essentuki-type drinking mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus].

The objective of the present study was to estimate the effectiveness of the spa and health resort-based treatment of non-alcoholic fatty liver disease in 40 patients at the mean age of 48,8 ± 5.7 years suffering from type 2 diabetes mellitus. All of them received combined therapy including the application of potable Essentuki-Novaya mineral water (20 patients) or Essentuki No 4 water (20 patients).

[From the Russian Balneological Society to innovative technologies of spa and health resort-based treatment. The 95th anniversary of the Pyatigorsk State Research Institute of Balneology].

This article is dedicated to the 95th anniversary of the Federal state budgetary institution "Pyatigorsk State Research Institute of Balneology", Russian Federal Medico-Biological Agency. The main stages of the development of the institution are described with special reference to its scientific achievements and the principal lines of current activities.

[The spa-and-health resort-based rehabilitation of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation].

Objective Of The Study: To develop a new medical technology for the spa-and-health resort-based treatment of the patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation.

Material And Methods: A total of 100 patients presenting with frequently recurring erosive and ulcerative lesions in the oesophagus, stomach, and duodenum in the phase of subsiding exacerbation were available for the examination that included detailed investigations of the clinical picture, characteristics of the immune status, and psychological testing before and after a course of the spa-and-health resort-based treatment. The effectiveness of two therapeutic modalities was evaluated.

[The use of plasma surgery in military medicine].

Scientists have been carrying out plasma energy research with the aim to apply to surgical practice. Domestic plasma devices "SUPR-M", "Fakel-01", "Gemoplaz-VP" and "Plazon" passed tests and were approved not only in clinical practice but also in condition of armed conflicts. Biological influence of air-plasma flows on tissues was examined.

[Hyperplastic processes in endometrium of women during prolonged menopause].

A total of 651 patients were available for observation during prolonged menopause. It was shown that fibrous-glandular polyps of endometrium occur much more frequently in such women than glandular and glandular-cystic hyperplasia (54.37 and 2.

[Peculiarities of diagnostics of hyperplastic processes in endometrium during long postmenopause].

Comparative characteristics of hyperplastic processes are presented based on the results of ultrasound and postoperative histological studies. The informative value of ultrasound diagnostics of hyperplastic processes in endometrium during long postmenopause was estimated at 60%. Up to 40% of such diagnoses were not confirmed by histological studies of the material obtained by differential curettage of cervical canal and uterine walls.