Publications by authors named "Effrosyni Gkrania-Klotsas"
Objectives: Our aim was to address existing knowledge gaps regarding risk stratification, best use of diagnostic resources, optimal treatment and general management of SARS-CoV-2 infection in solid organ transplant (SOT) recipients. As high-quality evidence specific to this fragile population is lacking, our final aim was to provide an expert consensus evidence-informed guidance that can aid clinicians in their daily practice.
Methods: This study was conducted within the Working Package 4 (WP4 - Fragile population cohorts) of the H2020 funded ORCHESTRA study [https://orchestra-cohort.
Article Synopsis
- - Rapid COVID-19 diagnosis is crucial in hospitals, but traditional nose/throat swabs often yield negative results for 30%-50% of patients using nucleic acid amplification testing (NAAT) for SARS-CoV-2.
- - The D614G spike mutant is prevalent, raising questions on how well existing antibody tests detect this variant compared to the original strain.
- - Combining rapid antibody point-of-care tests with NAAT significantly improves detection rates for COVID-19, achieving a sensitivity of 79.2% and maintaining high specificity regardless of the D614G variant.