Publications by authors named "Effrosyni A Chavli"
Article Synopsis
- Aneuploidy, an abnormal chromosome number, is common in human embryos and is a major cause of implantation failure and early pregnancy loss.
- Errors during meiosis and mitosis lead to karyotype abnormalities, with mitotic errors resulting in mosaicism, where cells have different genetic makeups within the same embryo.
- Using single-cell whole-genome sequencing on blastocysts, it was found that 82% exhibited mosaicism, often affecting less than 20% of cells, highlighting that traditional bulk DNA sequencing may miss significant genetic abnormalities in embryos previously deemed normal.
Background: Despite all research efforts during this era of novel time-lapse morphokinetic parameters, a morphological grading system is still routinely being used for embryo selection at the blastocyst stage. The blastocyst expansion grade, as evaluated during morphological assessment, is associated with clinical pregnancy. However, this assessment is performed without taking the dynamics of blastocoel expansion into account.
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