Publications by authors named "Eesha Irfanullah"
Cerebrospinal fluid (CSF) protein levels exhibit high variability in HIV-associated cryptococcal meningitis; however, its clinical implications remain unclear. We analyzed data from 890 adults with HIV-associated cryptococcal meningitis randomized into two clinical trials in Uganda between 2015 and 2021. CSF protein was grouped into < 100 mg/dl (72%, n = 641) and ≥ 100 mg/dl (28%, n = 249).
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- In a study of 890 adults with HIV-associated cryptococcal meningitis, researchers found that cerebrospinal fluid (CSF) protein levels varied significantly, impacting clinical outcomes.
- Approximately one-third of the participants had elevated CSF protein (≥100 mg/dL), leading to associations with more severe clinical presentations, such as impaired consciousness and seizures, but also indicated better fungal clearance and immune responses.
- The study concluded that higher CSF protein levels could be a useful indicator for immune activation and could help predict patient prognosis in cryptococcal meningitis.
Article Synopsis
- There is a growing need for accessible surgical simulation training in low-resource countries, prompting a pilot workshop at a new simulation center to evaluate low-cost training models.
- The workshop engaged local educators, who were trained using hybrid-fidelity simulation models created from inexpensive materials, effectively preparing them to teach essential clinical skills to anesthesiology trainees.
- Survey results indicated high satisfaction with the training models, with 100% ranking the pericardiocentesis simulator as "good" or "outstanding," highlighting the importance of collaboration to enhance surgical education in lower middle-income countries.
Unlabelled: Upper extremity (UE) fractures are prevalent age-related fractures, and stair-associated falls are a common mechanism for these injuries. Our study has identified an increasing incidence of stair-related UE fractures and associated hospitalization rates among the older United States population between 2012-2021. Targeted prevention efforts should be implemented by health systems.
View Article and Find Full Text PDFIntroduction: Children under the age of 5 years suffer from the highest rates of fall-related injuries. Caretakers often leave young children on sofas and beds, however, falling and rolling off these fixtures can lead to serious injury. We investigated the epidemiologic characteristics and trends of bed and sofa-related injuries among children aged <5 years treated in US emergency departments (EDs).
View Article and Find Full Text PDFAn important quality attribute of a recombinant adeno-associated virus (rAAV) as a therapeutic vector is its infectivity. Current assays to quantify infectious rAAV rely on coinfection with a helper virus such as adenovirus (Ad), which requires helper virus preparation and introduces additional variability. A simple method that has high sensitivity and removes the need for helper virus would improve assay consistency and facilitate high-throughput applications such as rAAV producer cell line development.
View Article and Find Full Text PDFRecombinant adeno-associated viruses (rAAV) are important gene delivery vehicles for gene therapy applications. Their production relies on plasmid transfection or virus infection of producer cells, which pose a challenge in process scale-up. Here, we describe a template for a transfection-free, helper virus-free rAAV producer cell line using a synthetic biology approach.
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