Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.

Aim: To recognize genetic associations of hydrochlorothiazide-induced change in serum uric acid (SUA) concentration.

Patients & Methods: We conducted a genome-wide association study on hydrochlorothiazide-induced change in SUA in 214 Finnish men from the GENRES study. Replication analyses were performed in 465 Finns from the LIFE study.