In the anticipation of threat: Neural regulatory activity indicated by delta-beta correlation and its relation to anxiety.

The anticipation of oncoming threats is emotionally challenging and related to anxiety. The current study aimed to investigate the neural regulatory processes during the anticipatory preparations in stressful situations in relation to trait anxiety, especially in an uncertainty-related stressful situation. To this end, we measured within-subjects delta-beta amplitude-amplitude correlation (AAC) and phase-amplitude coupling (PAC) with electroencephalography using a well-defined stress-inducing paradigm in 28 high-trait-anxiety (HTA) and 29 low-trait-anxiety (LTA) college students.

DARTpaths, an in silico platform to investigate molecular mechanisms of compounds.

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied to predict developmental and reproductive toxicity (DART) and implemented into an in silico platform, called DARTpaths.

Availability And Implementation: All code is available on GitHub https://github.

The gonadal response to social stress and its relationship to cortisol.

The cortisol response to social evaluative stress has been well characterized. However, data regarding changes in gonadal hormones after stress are still scarce and inconsistent. The majority of studies have focused on testosterone reactivity to stress in men, while estradiol responses or gonadal stress responses in women have hardly been investigated.

Delta-beta cross-frequency coupling as an index of stress regulation during social-evaluative threat.

Coupling between delta (1-4 Hz) and beta (14-30 Hz) oscillations is posited to reflect subcortico-cortical communication and stress regulation. To validate delta-beta coupling (DBC) as an index of neural stress regulation, we investigated whether DBC changes during stress and whether these changes are associated with established stress responses. We induced stress using a social-evaluative threat (impromptu speech) task and measured frontal and parietal delta-beta amplitude-amplitude correlation (AAC) and phase-amplitude coupling (PAC), as well as cardiovascular, affective, and endocrine stress responses.

Reflecting on Existential Threats Elicits Self-Reported Negative Affect but No Physiological Arousal.

There is mixed evidence whether reflecting on an existential threat increases negative affect and thereby elicits subjective arousal and physiological activation. Additionally, it is debated whether different existential and non-existential threats elicit different arousal responses, although systematic comparisons are lacking. The current study explored affective, subjective, and physiological arousal responses while comparing several existential threats with a non-existential threat and with a control condition.

Data for "Social-evaluative threat: Stress response stages and influences of biological sex and neuroticism".

This Data In Brief article contains supplementary materials to the article "Social-evaluative threat: stress response stages and influences of biological sex and neuroticism" [1], and describes analysis results of an open dataset [2]. Additional information is provided regarding the methods, particularly: the analysis of individual stress response peak times per stress system, and the statistical analysis. Importantly, correlation tables are presented between the different stress systems, both for baseline stress levels as well as for stress responses, and significant associations are displayed in scatter plots.

Social-evaluative threat: Stress response stages and influences of biological sex and neuroticism.

Social-evaluative threat (SET) - when the self could be negatively judged by others - can cause pronounced responses in the different stress systems: threat/challenge appraisal, the sympathetic (SNS) and parasympathetic (PNS) nervous systems, experienced motivation and affect, and the hypothalamus-pituitary-adrenal (HPA) axis. Here, we utilize a four-stage stress response model to shed light on the complex associations between different stress responses, where earlier stages are hypothesized to predict later stages. Additionally, we take into account important moderators, such as biological sex (controlling for menstrual cycle phase), personality traits (neuroticism and extraversion), and baseline stress levels.

Frontal delta-beta cross-frequency coupling in high and low social anxiety: An index of stress regulation?

Cross-frequency coupling (CFC) between frontal delta (1-4 Hz) and beta (14-30 Hz) oscillations has been suggested as a candidate neural correlate of social anxiety disorder, a disorder characterized by fear and avoidance of social and performance situations. Prior studies have used amplitude-amplitude correlation (AAC) as a CFC measure and hypothesized it as a candidate neural mechanism of affective control. However, using this metric has yielded inconsistent results regarding the direction of CFC, and the functional significance of coupling strength is uncertain.

Fear of negative evaluation modulates electrocortical and behavioral responses when anticipating social evaluative feedback.

Cognitive models posit that the fear of negative evaluation (FNE) is a hallmark feature of social anxiety. As such, individuals with high FNE may show biased information processing when faced with social evaluation. The aim of the current study was to examine the neural underpinnings of anticipating and processing social-evaluative feedback, and its correlates with FNE.