Transcriptomic analysis of multi-drug resistant K-12 strain in response to essential oil.

To better understand the synergistic antibacterial activity between piperacillin and essential oil (LEO) against multidrug-resistant , we performed microarray transcriptomic analysis of LEO when used alone and in combination with piperacillin against the non-treated control. In total, 90 genes were differentially expressed after the combination of LEO and piperacillin treatment. Among the up-regulated genes, , are known to control microbial metabolism and nitrotoluene degradation, which were observed only in the LEO-piperacillin combinatory treatment.