Publications by authors named "Ee-Lin Toh"
Article Synopsis
- - The study analyzed over 373,000 single-cell transcriptomes from colorectal cancer patients to better understand the diversity of epithelial cells, revealing distinct genetic and gene expression differences among malignant cells.
- - Two new intrinsic subtypes, iCMS2 and iCMS3, were identified, with iCMS3 linked to worse outcomes and encompassing both microsatellite unstable (MSI-H) and some microsatellite-stable (MSS) cancers.
- - The research proposes a refined 'IMF' classification that incorporates intrinsic epithelial subtype, microsatellite instability status, and fibrosis, leading to five distinct subtypes of colorectal cancer.
Background: Elective colorectal cancer (CRC) surgeries offer enhanced surgical outcomes but demand high self-efficacy in prehabilitation and competency in self-care and disease management postsurgery. Conventional strategies to meet perioperative needs have not been pragmatic, and there remains a pressing need for novel technologies that could improve health outcomes.
Objective: The aim of this paper was to describe the development of a smartphone-based interactive CRC self-management enhancement psychosocial program (iCanManage) in order to improve health outcomes among patients who undergo elective CRC surgeries and their family caregivers.
Mesenteric lymphangiomas are relatively rare, with clinical symptoms ranging from an asymptomatic presentation to an acute abdomen. The natural history and biological behaviour of this entity can range from slow indolent lesions to aggressive tumours with a risk of malignant transformation. Spontaneous regression of a mesenteric lymphangioma is rare.
View Article and Find Full Text PDFAim: To critically appraise short-term outcomes in patients treated in a new Pelvic Exenteration (PE) Unit.
Methods: This retrospective observational study was conducted by analysing prospectively collected data for the first 25 patients (16 males, 9 females) who underwent PE for advanced pelvic tumours in our PE Unit between January 2012 and October 2016. Data evaluated included age, co-morbidities, American Society of Anesthesiologists (ASA) score, Eastern Cooperative Oncology Group (ECOG) status, preoperative adjuvant treatment, intra-operative blood loss, procedural duration, perioperative adverse event, lengths of intensive care unit (ICU) stay and hospital stay, and oncological outcome.