Cytotoxic Action of N-aryl, Furan-derived Aminophosphonates against HT29 and HCT116 Cancer Cell Lines.

Background: The anticancer activity of aminophosphonic derivatives has been described extensively, some recent papers included furan-derived aminophosphonates and their cytostatic action against various cancer cells.

Objective: A series of twelve furan-derived dibenzyl and diphenyl aminophosphonates 2a-f and 3a-f was synthesized and tested in aspect of their cytotoxic action on two cell lines of colorectal cancer: HT29 and HCT116. Seven of them are new compounds, while the rest five have already been published by us, together with their cytotoxic action against squamous esophageal cancer cells.

Convenient Synthesis of [closo-BH-1-I] and [closo-BH-1,10-I] Anions.

Two iodo derivatives, [closo-BH-1-I] (1) and [closo-BH-1,10-I] (2), were obtained from the parent [closo-BH] anion in a two-step process and about 60% and 80% overall yields, respectively. Molecular and crystal structures of 2[PrN] were established with XRD methods: I422; a = b = 10.1531(1) Å, c = 18.