Treatment of severe primary IGF-1 deficiency using rhIGF-1 preparation - first three years of Polish experience.

Introduction: The objective of this study was to analyse the effects of the first three years of treatment with recombinant human insulinlike growth factor 1 (rhIGF-1) in patients from the Polish population.

Material And Methods: Twenty-seven children (22 boys and five girls) aged 2.8 to 16.

[Correlation between intima-media thickness in carotid artery and markers of epithelial cell dysfunction in patients with juvenile idiopathic arthritis].

Unlabelled: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. Prolonged immunological inflammatory process leads in these patients to an early onset of atherosclerosis. That is why it seems to be important to find methods of detecting atherosclerosis in its very early stage to start appropriate treatment.

[Early atherosclerosis changes in children with juvenile idiopathic arthritis].

Unlabelled: Pathogenesis of the two diseases: juvenile idiopathic arthritis (JIA) and atherosclerosis are similar-they include increased inflammation markers, homocysteine and lipids levels, inflammatory cytokines. It seems to be important to look for new diagnostic methods to find atherosclerosis in early stage- ultrasonography of the carotid artery with intima-media thickness (IMT) measurement and serum homocysteine level. The aim of this study was assessment of preclinical markers of atherosclerosis--concentration of homocysteine and IMT MATERIAL AND METHODS: The study group consists of 40 children with JIA (20 girls and 20 boys) aged 4-16 years; 32 children with oligoarthritis JIA and 8--polyarthritis JIA.

[Composition of linoleic and arachidonic acids in phosphatidylcholine of erythrocytes membrane and IL-6 and TNF-alpha in serum and C-reactive protein concentration in children with juvenile idiopathic arthritis].

Unlabelled: The study objective was to determine the relationship, if any, between the levels of arachidonic and linoleic acids in erythrocyte membrane phosphatidylcholine (PCH), serum interleukin 6 (IL-6) and TNFalpha levels and C-reactive protein (CRP) in juvenile idiopathic arthritis (JIA).

Materials And Methods: The study involved 49 children with JIA, aged 3-18 years (mean 11.3 +/- 3.

[Lipids and homocysteine level in juvenile idiopathic arthritis].

We investigated serum levels of lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglicerides), homocysteine, C-reactive protein (CRP) in 25 children with juvenile idiopathic arthritis (JIA) and 15 healthy control. We found statistically significant increase of total cholesterol, LDL-cholesterol, triglicerides (p<0.05) and decreased of HDL-cholesterol (p<0.

[Cytokine levels in serum of patients with juvenile idiopathic arthritis depending on subtype and disease activity].

We investigated serum levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) in 25 patients with juvenile idiopathic arthritis (JIA) during both: active and inactive phases of the disease. The polyarticular JIA patients had the highest IL-6 level during both active and inactive periods, TNFalpha level was the highest in the systemic JIA, active and inactive periods. IL-6 and TNFalpha levels were significantly lower than those of controls (p<0.