Publications by authors named "Edyta Laska"
Article Synopsis
- Colorectal cancer (CRC) is a significant health issue globally, being the third most common cancer and a leading cause of death, although rates have generally decreased due to increased awareness and early detection through screening.
- The study investigated the impact of colonoscopy on CRC incidence and explored relationships with family cancer history and symptom-to-treatment timelines, revealing a significant link between colonoscopy and CRC incidence.
- Despite overall improvements, the rising incidence of CRC in individuals under 50 highlights the need for effective screening and timely treatment, which is critical for improving outcomes.
Incidence versus treatment outcomes and survival in patients before age 40 with colorectal cancer.
Pol Przegl Chir
February 2024
<b><br>Introduction:</b> Colorectal cancer (CRC) was the third most common cancer and the second cause of cancer deaths worldwide in 2020. Its incidence has increased dramatically in people under 50 years of age (early-onset colorectal cancer; EOCRC).</br> <b><br>Aim:</b> The aim of this study was to compare two age groups of patients with colorectal cancer in terms of stage, prognostic factors, survival and incidence of recurrence.
View Article and Find Full Text PDFThe chemical synthesis of five new metabolically stabilized 2-OMe-LPA analogues (1a-e) possessing different fatty acid residues has been performed by phosphorylation of corresponding 1-O-acyl-2-OMe-glycerols which were prepared by multistep process from racemic glycidol. The now analogues were subjected to biological characterization as autotaxin inhibitors using the FRET-based, synthetic ATX substrate FS-3. Among tested compounds 1-O-oleoyl-2-OMe-LPA (1e) appeared to be the most potent, showing ATX inhibitory activity similar to that of unmodified 1-O-oleoyl-LPA.
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