Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics.

Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV-1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression.

M: Cross-sectional data on 5152 (56.

Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland.

Introduction: Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from Poland.

Material And Methods: Maximum likelihood phylogenenetic trees were inferred from 966 HIV-1 subtype B protease/reverse transcriptase sequences from patients followed up in nine Polish HIV centers.

Distribution and time trends of HIV-1 variants in Poland: Characteristics of non-B clades and recombinant viruses.

The spread of HIV-1 subtypes varies considerably both worldwide and within Europe, with non-B variants commonly found across various exposure groups. This study aimed to analyse the distribution and temporal trends in HIV-1 subtype variability across Poland. For analysis of the subtype distribution, 1219 partial pol sequences obtained from patients followed up in 9 of 17 Polish HIV treatment centres were used.

Time trends in HIV-1 transmitted drug resistance mutation frequency in Poland.

Introduction: In Poland, the HIV epidemic has shifted recently from being predominantly related to injection drug use (IDU) to being driven by transmissions among men-who-have-sex-with-men (MSM). The number of new HIV cases has increased in the recent years, while no current data on the transmitted drug resistance associated mutations (tDRM) frequency trend over time are available from 2010. In this study, we analyze the temporal trends in the spread of tDRM from 2008 to 2013.

Transmitted HIV drug resistance in antiretroviral-treatment-naive patients from Poland differs by transmission category and subtype.

Objectives: The surveillance of HIV-transmitted drug resistance mutations (t-DRMs), including temporal trends across subtypes and exposure groups, remains a priority in the current management of the epidemic worldwide.

Methods: A cross-sectional analysis of 833 treatment-naive patients from 9 of 17 Polish HIV treatment centres. Partial pol sequences were used to analyse drug resistance with a general time reversible (GTR)-based maximum likelihood algorithm used for cluster/pair identification.

Human meningitis caused by Streptococcus suis.

Streptococcus suis is an important swine pathogen worldwide, which can be transmitted to human beings by direct contact; therefore, S. suis infections occur mainly in people who handle pigs or pork. We present a case of a patient with S.

[HIV preexposure prophylaxis].

The pre-exposure chemoprophylaxis (PrEP) is an experimental approach to HIV prevention. The use of antiretroviral drugs has been shown to be effective in prevention HSIV infection in animals. The results from ongoing clinical PrEP trials have demonstrated that antiretrovirals were able to reduce HIV incidence in women and men.

[HIV infection in women in childbearing age].

HIV infected women compromise about half of all people living with HIV worldwide. Since HIV is frequently sexually transmitted it follows that women who are seropositive are likely to acquire other sexually transmitted diseases. The gynecologic infections led enhance HIV replication and increased transmission of virus.

[Tuberculosis among HIV infected patients].

The aim of study was to determine clinical presentation and outcome of tuberculosis among patients infected with human immunodeficiency virus type 1 (HIV-1). During 2001-2006, 36 cases of tuberculosis (TB) was recognized in 33 patients infected with HIV. The majority of patients were men infected with HIV in through intravenous drug using and had a CD4 cell count <200cells/microl at the time of TB diagnosis.

[Morphological liver changes of chronic hepatitis C in antiretroviral-naive HIV-infected patients].

Unlabelled: The aim of the study was evaluation of morphological exponents of chronic hepatitis C in naive HIV/HCV co-infected patients.

Material And Methods: Investigation were performed in 61 patients with chronic hepatitis C, 21 HIV co-infected. HIV-HCV co-infected patients were included to group I.

[Serum IL-2 and sIL-2R concentration in children with chronic hepatitis B].

Unlabelled: The aim of the study was evaluation of serum IL-2 and sIL-2R concentration in children with chronic hepatitis B without previous treatment.

Material And Methods: Investigations were performed on sera from 27 children, 13 HBsAg and HBeAg positive (group I) and 14 HBsAg positive, HBeAg negative, anti-HBe positive (group II). Serum IL-2 and sIL-2R concentrations were detected with ELISA method.

[HIV and HCV infections--clinical implications].

Coexisting HIV and HCV infection involves approx. 10 million people in the world. It is most common in drug addicts taking drug injections as well as in haemophiliacs.