Synthesis and Anticancer Evaluation of Novel Derivatives of Isoxazolo[4,5-][1,2,4]triazepine Derivatives and Potential Inhibitors of Protein Kinase C.

In the present study, using Thorpe's reaction with Gewald's modification, 4-acetylamino-5-acetyl or 5-benzoyl 3-carboxamide compounds or were obtained. From these compounds, two series of compounds (, , and and , , and ) were obtained with 98% hydrazine. Compounds , , , and were then reacted with the appropriate aldehydes to afford a series of new isoxazole derivatives (, , and ) and the main compounds, and , were isoxazolo[4,5-][1,2,4]triazepine derivatives.

Synthesis and anticancer evaluation of novel 3,5-diaryl-thiazolo[4,5-]pyrimidin-2-one derivatives.

The 2-oxo analogs of thiazolo[4,5-]pyrimidine-2-thiones were prepared to study their cytotoxic activity. Five of the newly synthesized compounds were selected by the National Cancer Institute (Bethesda, MD, USA) for a primary in vitro antitumor assay. 7-Chloro-3,5-diphenyl-thiazolo[4,5-]pyrimidin-2-one () proved to be the most active one among the screened derivatives and was further evaluated in the full panel of 60 cell lines at five different concentrations.

Synthesis and antitumor screening of novel 3-phenylthiazolo [4,5-d]pyrimidin-2-thione derivatives.

A series of new derivatives of 3-phenylthiazolo[4,5-d]pyrimidine-2-thiones were synthesized by the cyclization of 4-amino-5-alkyl(aryl) carboxamido-2,3-dihydrothiazolo-2-thione with aromatic aldehydes. Amine moieties were substituted in position 7 of the obtained bicyclic compounds. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, and 13C-NMR spectral data.

Beyond "objective" and "projective": a logical system for classifying psychological tests: comment on Meyer and Kurtz (2006).

I present a formal system that accounts for the misleading distinction between tests formerly termed objective and projective, duly noted by Meyer and Kurtz (2006). Three principles of Response Rightness, Response Latitude and Stimulus Ambiguity are shown to govern, in combination, the formal operating characteristics of tests, producing inevitable overlap between "objective" and "projective" tests and creating at least three "types" of tests historically regarded as being projective in nature. The system resolves many past issues regarding test classification and can be generalized to include all psychological tests.

Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine.

A number of derivatives of isoxazolo[4,5-d]pyrimidine were prepared with structures similar to that of purine. Condensation of the hydrazide of 4-amino-5-benzoylisoxazolo-3-carboxylic acid 2 with ethyloxalyl chloride followed by cyclization gave 3-oxdiazolo-[1,3,4]-4-amino-5-benzoylisoxazole 7 which, upon cyclization with acetonitrile followed by reactions with different amines, gave derivatives of isoxazolo[4,5-d]pyrimidine 9 and 10d-g. Compounds 8g and 10f were tested for their effects on the immune response in the mouse model.

Synthesis and pharmacological assessment of derivatives of isoxazolo[4,5-d]pyrimidine.

A series of new 5-alkyl and 5-arylisoxazolo[4,5-d]pyrimidinones (5a-g, 6-8) were prepared from 4-amino-3-oxo-isoxazolidine-5-carboxylic acid amide. Some of the aryl derivatives of isoxazolo[4,5-d]pyrimidine were tested pharmacologically in comparison with Diazepam. Compounds 5b-d and 7 demonstrated interesting anxiolytic activity.

Using broad measures of maladjustment to assess psychological states of outpatients with schizophrenia.

Two broad indexes of maladjustment derived from two projective tests and administered at two separate points to the same 50 outpatients with schizophrenia showed substantial convergent validity at both testings (r=.52, p<.001; r=.

Defining projective techniques: finding common ground for discourse.

In 2000 Lilienfeld, Wood, and Garb defined projective tests in a traditional yet loose manner. When a more precise and exclusive definition is furnished, two classes of responses indicative of deviancy can be logically derived. It is suggested that a focused review of the literature yields consistent relations between psychopathology and two response types, falsifications and misrepresentations.

Differences on the projective hand test among chronic pain patients reporting three different pain experiences.

This study examined personality differences among individuals experiencing 3 different types of pain. The projective Hand Test was administered to 90 individuals who were seeking treatment at a pain clinic in an urban area of the southeast United States. These people were seeking treatment for either arthritis (n = 31), fibromyalgia (n = 29), or migraine headaches (n = 30).