Publications by authors named "Edwin Tam"

The efficiency of the resource recovery system in the automobile industry is not well understood. The effectiveness of resources recovery for used oil, filters and containers in four Canadian provinces were assessed from 2010 to 2022. The collection rates of resources, financial performance, and temporal changes of two original indicators: Resource Recovery Per Vehicle (RRPV), and Expenses Per Vehicle (EXPV) were examined.

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Background: e-Health tools using validated questionnaires to assess outcomes may facilitate measurement-based care for psychiatric disorders. MoodFX was created as a free online symptom tracker to support patients for outcome measurement in their depression treatment. We conducted a pilot randomized evaluation to examine its usability, and clinical utility.

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Article Synopsis
  • Unfractionated heparin (UFH) is used to prevent and treat blood clots, with dosages typically based on weight, but the study aimed to compare the effectiveness of fully weight-based dosages to non-weight-based titrations after a protocol change in 2019.
  • The study was a retrospective, observational analysis comparing two groups of patients: one treated under the previous fully weight-based protocol (2015-2016) and another under the newer non-weight-based protocol (2020).
  • Results showed similar effectiveness in achieving the desired anticoagulation levels, with both groups needing a median of one dosage adjustment; however, the fully weight-based group had a slightly higher rate
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Corrosion can compromise the integrity of the vehicle. Instead, "rust proofing" a vehicle can prolong its usable life span, reducing material waste overall and permitting greater salvageability at the end of the vehicle's life. For rust proofing, a definitive and consistent approach for detecting corrosion could be beneficial.

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This research outlines a digital imaging method under development to systemize a rapid in-field corrosion evaluation measure, to evaluate and monitor the degree of corrosion on target corrosion-prone parts on light-duty vehicles. This procedure uses digital imaging to study and compare corrosion levels of 228 vehicles that were treated with aftermarket applications of corrosion prevention products versus 141 vehicles that were untreated. It introduces a Corrosion Index (CI) as a common measure.

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Objectives: To determine the efficacy and safety of blue-light therapy in seasonal and non-seasonal major depressive disorder (MDD), by comparison to active and inactive control conditions.

Methods: We searched Web of Science, EMBASE, Medline, PsycInfo, and Clinicaltrials.gov through January 17, 2022, for randomized controlled trials (RCTs) using search terms for blue/blue-enhanced, light therapy, and depression/seasonal affective disorder.

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Background: Bright light therapy has been shown to improve depressive symptoms in patients with nonseasonal major depressive disorder (MDD) but there are few studies examining functional outcomes.

Methods: We examined secondary functional outcomes in the 8-week randomized, placebo-sham-controlled LIFE-D trial comparing light therapy, fluoxetine, and the combination in patients with nonseasonal MDD. Functional assessments included the Sheehan Disability Scale (SDS) and, for employed participants, the Lam Employment Absence and Productivity Scale (LEAPS).

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Objective: Bright light therapy is increasingly recommended (alone or in combination with antidepressant medication) to treat symptoms of nonseasonal major depressive disorder (MDD). However, little is known about its impacts on quality of life (QoL), a holistic, patient-valued outcome.

Methods: This study utilizes secondary outcome data from an 8-week randomized, controlled, double blind trial comparing light monotherapy ( = 32), fluoxetine monotherapy ( = 30), and the combination of these ( = 27) to placebo ( = 30).

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Article Synopsis
  • Patients with major depressive disorder (MDD) often struggle with cognitive issues like memory and concentration that affect their job performance.
  • A study involving 36 MDD patients treated with desvenlafaxine found that self-reported cognitive difficulties correlated with work functioning outcomes.
  • Significant improvements were observed in cognitive and work-related measures after treatment, highlighting the usefulness of cognitive self-report questionnaires in tracking changes and predicting work performance improvements.
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Objective: We previously reported that morning bright light therapy is efficacious in adults with nonseasonal major depressive disorder (MDD), both on its own and in combination with fluoxetine. Given that appetitive symptoms predict response to bright light therapy in seasonal depression, we examined, in this secondary analysis, whether the same held true in these nonseasonal MDD patients.

Methods: Data were collected from October 7, 2009, to March 11, 2014.

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Fatigue and low energy are cardinal symptoms of major depressive disorder (MDD) that have an impact on work functioning. Antidepressants with noradrenergic activity have been hypothesized to improve symptoms of fatigue and low energy. We examined the impact of these symptoms on work functioning in patients with MDD treated with the serotonin and noradrenaline reuptake inhibitor, desvenlafaxine.

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Article Synopsis
  • * In a study with 36 employed adults with moderate MDD, participants underwent neurocognitive testing and assessments of work performance before and after 8 weeks of treatment with desvenlafaxine, which showed overall improvements in depressive symptoms and functioning.
  • * Although there were no direct correlations found between cognitive improvements and enhancements in work performance, those who showed notable neurocognitive gains experienced greater overall improvements in their mental health and job functioning compared to those who did not.
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Importance: Bright light therapy is an evidence-based treatment for seasonal depression, but there is limited evidence for its efficacy in nonseasonal major depressive disorder (MDD).

Objective: To determine the efficacy of light treatment, in monotherapy and in combination with fluoxetine hydrochloride, compared with a sham-placebo condition in adults with nonseasonal MDD.

Design, Setting, And Participants: Randomized, double-blind, placebo- and sham-controlled, 8-week trial in adults (aged 19-60 years) with MDD of at least moderate severity in outpatient psychiatry clinics in academic medical centers.

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Background: Animals show seasonal changes in the endocrine and immune system in response to winter stressors. Even though increased inflammation has been implicated in the pathophysiology of depression, whether immune disorder is a key mediator in seasonal affective depression (SAD) is unknown. Here, we hypothesized that short photoperiods in winter may induce inflammatory response, which contributes to SAD, and that light treatments should normalize immune function and improve depressive symptoms.

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Plastics are increasingly a preferred material choice in designing and developing complex, consumer products, such as automobiles, because they are mouldable, lightweight, and are often perceived to be highly recyclable materials. However, actually recycling the heterogeneous plastics used in such durable items is challenging, and presents very different scenarios to how simple products, such as water bottles, are recovered via curbside or container recycling initiatives. While the technology exists to recycle plastics, their feasibility to do so from high level consumer or industrial applications is bounded by technological and economical restraints.

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Background: Major depressive disorder is associated with significant impairment in occupational functioning and reduced productivity, which represents a large part of the overall burden of depression.

Aims: To examine symptom-based and work functioning outcomes with combined pharmacotherapy and psychotherapy treatment of major depressive disorder.

Method: Employed patients with a DSM-IV diagnosis of major depressive disorder were treated with escitalopram 10-20 mg/day and randomised to: (a) telephone-administered cognitive-behavioural therapy (telephone CBT) (n = 48); or (b) adherence-reminder telephone calls (n = 51).

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Plastics continue to be a challenge for recovering materials at the end-of-life for vehicles. However, it may be possible to improve the recovery of plastics by exploiting material characteristics, such as shape, or by altering their behavior, such as through temperature changes, in relation to recovery processes and handling. Samples of a 2009 Dodge Challenger front fascia were shredded in a laboratory-scale hammer mill shredder.

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Background. Major depressive disorder (MDD) is associated with significant impairment in occupational functioning. This study sought to determine which depressive symptoms and medication side effects were perceived by patients with MDD to have the greatest interference on work functioning.

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Background: Chronic depression is a particularly disabling mood disorder and treatment outcomes are poor with either psychotherapy or pharmacotherapy alone. There is growing evidence that an integrative treatment approach may be optimal. A novel multi-modal, multi-disciplinary treatment program, Re-ChORD, was developed at the University of British Columbia and evaluated in this pilot study.

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Background: Recent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD).

Methods: The efficacy of a LED light therapy device in the treatment of SAD was tested in a randomized, double-blind, placebo-controlled, multi-center trial.

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Background: Although a host of studies have now examined the relationship between quality of life (QoL) and non-seasonal depression, few have measured QoL in seasonal affective disorder (SAD). We report here on results from the Can-SAD trial, which assessed the impact of treatment with either antidepressant medication or light therapy upon QoL in patients diagnosed with SAD.

Method: This Canadian double-blind, multicentre, randomized controlled trial included 96 patients who met strict diagnostic criteria for SAD.

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Objective: Light therapy and antidepressants have shown comparable efficacy in separate studies of seasonal affective disorder treatment, but few studies have directly compared the two treatments. This study compared the effectiveness of light therapy and an antidepressant within a single trial.

Method: This double-blind, randomized, controlled trial was conducted in four Canadian centers over three winter seasons.

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Objective: To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months.

Methods: Twenty-six patients who were enrolled in an ongoing multicentre study in Canada completed 2 measures of QoL (the 20-item Medical Outcomes Study Short-Form General Health Survey [SF-20] and the Quality of Life Enjoyment and Satisfaction Questionnaire, [Q-LES-Q]) during the winter, when suffering from depression, and again during the summer months.

Results: Both general and health-related QoL scores were significantly improved in patients with SAD during the summer months, with scores for the most part falling within normal range.

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Although a relatively large body of research has now accumulated concerning the relationship between quality of life (QoL) and nonseasonal depression, there is a dearth of information about QoL in seasonal affective disorder (SAD). The aim of this study was to compare perceived levels of broad ('generic') and health-related QoL in patients with seasonal and nonseasonal depression. Participants were 72 patients with SAD enrolled in an on-going multicentre study in Canada, and 72 patients with nonseasonal major depressive disorder (MDD) matched for severity of depression attending an outpatient psychiatric clinic in Vancouver, British Columbia.

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Although a large body of research has accumulated concerning the relationship between nonseasonal depression and personality, comparatively few studies have examined the relationship between seasonal affective disorder (SAD) and personality. This study compared dimensional aspects of personality in patients diagnosed with SAD (N = 60), nonseasonal depression (N = 273), and nonclinical controls (N = 297) using the Dimensional Assessment of Personality Pathology (DAPP-BQ; Livesley & Jackson, in press). Analysis by ANCOVA indicated that significant between-group differences occurred in several of the 18 DAPP-BQ dimensions, with patients with SAD exhibiting personality psychopathology that was intermediate between the nonclinical sample and patients with nonseasonal depression.

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