Publications by authors named "Edwin Kin-Wai Chan"
Article Synopsis
- - This study focused on understanding portal hypertension (PHT) and its predictors in patients who survived biliary atresia (BA) after undergoing a surgical procedure called Kasai portoenterostomy (KPE).
- - Researchers analyzed data from 320 patients across six centers in East Asia, finding that 37.8% developed PHT by five years post-KPE, particularly those who had the surgery later in life.
- - Key findings revealed that higher bilirubin levels at one year post-KPE are linked to increased PHT risk, highlighting the importance of early surgery and ongoing monitoring for patients showing persistent jaundice.
We present a 37 years' experience in the management of biliary atresia (BA) and discuss long-term complications after Kasai portoenterostomy (KPE). A retrospective territory-wide study from 1980 to 2017 on 231 patients with open KPE from three tertiary paediatric surgical centres was performed. Outcome parameters were clearance of jaundice (COJ), native liver survival (NLS) and long-term complications.
View Article and Find Full Text PDFBackground/purpose: Short segment Hirschsprung's disease (HSCR) carries a better prognosis than long segment disease, but the definition of short is controversial. The objective of this study is to determine anatomically the extent of disease involvement that would be associated with a better functional outcome.
Methods: This is a retrospective multicenter (n = 3) study with patients (≥ 3 years) who had transanal pullthrough operation done for aganglionosis limited to the recto-sigmoid colon were reviewed.
Background: Biliary Atresia (BA) is rare and genetically complex, and the pathogenesis is elusive. The disease course is variable and can represent heterogeneity, which hinders effective disease management. Deciphering the BA phenotypic variance is a priority in clinics and can be achieved by the integrative analysis of genotype and phenotype.
View Article and Find Full Text PDFBackground: Assessing the role of laparoscopy in the management of intussusception.
Methods: A retrospective review of children aged up to 17 years who had surgery for intussusception at this institution between 1 January 2004 and 31 December 2013.
Results: The cohort of 44 individuals (18 females) presented at a median age of 9 months (range 2.
Background & Aims: Biliary atresia (BA) is a rare and most severe cholestatic disease in neonates, but the pathogenic mechanisms are unknown. Through a previous genome wide association study (GWAS) on Han Chinese, we discovered association of the 10q24.2 region encompassing ADD3 and XPNPEP1 genes, which was replicated in Chinese and Thai populations.
View Article and Find Full Text PDF