Pattern of Dental Emergencies at a Pediatric Tertiary Care Hospital during the COVID-19 Pandemic: A Retrospective Study.

Background: The onset of the COVID-19 pandemic and government restrictions affecting dental health care professionals had an impact on pediatric dental emergency trends. The purpose of this study was to describe the effect of the COVID-19 pandemic on the characteristics, outcomes and management of pediatric dental emergencies in a single tertiary care hospital.

Methods: A retrospective review of children presenting to Montreal Children's Hospital for dental emergencies before and during the pandemic was conducted.

Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis.

Background: Biliary Atresia (BA) is rare and genetically complex, and the pathogenesis is elusive. The disease course is variable and can represent heterogeneity, which hinders effective disease management. Deciphering the BA phenotypic variance is a priority in clinics and can be achieved by the integrative analysis of genotype and phenotype.

Longitudinal Cohort Study of Regenerative Endodontic Treatment for Immature Necrotic Permanent Teeth.

Introduction: The treatment of immature necrotic permanent teeth presents several clinical challenges in endodontics. Regenerative endodontic procedures (REPs) permit root development, increased canal wall thickness, and apical closure. This longitudinal cohort study aimed to evaluate the long-term clinical and radiographic outcomes of REPs of immature necrotic permanent teeth over a 30-month period.

What is the role of laparoscopic surgery in intussusception?

Background: Assessing the role of laparoscopy in the management of intussusception.

Methods: A retrospective review of children aged up to 17 years who had surgery for intussusception at this institution between 1 January 2004 and 31 December 2013.

Results: The cohort of 44 individuals (18 females) presented at a median age of 9 months (range 2.

Common genetic variants regulating ADD3 gene expression alter biliary atresia risk.

Background & Aims: Biliary atresia (BA) is a rare and most severe cholestatic disease in neonates, but the pathogenic mechanisms are unknown. Through a previous genome wide association study (GWAS) on Han Chinese, we discovered association of the 10q24.2 region encompassing ADD3 and XPNPEP1 genes, which was replicated in Chinese and Thai populations.

Root Cause Investigation of Rubber Seal Cracking in Pre-filled Cartridges: Ozone and Packaging Effects.

Unlabelled: Pre-filled syringes/cartridges as primary packaging for parenterally delivered biopharmaceutical liquids consist of multiple components, including containers made of glass or plastic, and stoppers/plungers and disk seals (septa) made of rubber materials. Cracking of rubber components may be cosmetically unacceptable and in extreme cases may compromise enclosure integrity. The purpose of this study was to investigate the root cause of septum cracking and evaluate parameters/solutions to delay or prevent cracking from occurring.

Site-specific tryptophan oxidation induced by autocatalytic reaction of polysorbate 20 in protein formulation.

Purpose: Tryptophan (Trp) oxidation leading to atypical degradation of a protein (Fab) formulated with polysorbate 20 (PS20) was investigated. Such atypical Trp oxidation was discussed in relation to a kinetic model that involves initiation of oxidizing free radical through an autocatalytic reaction.

Methods: Ion-exchange chromatography and peptide mapping were used to determine Trp oxidation.

Hypertrophic pyloric stenosis in a newborn: a diagnostic dilemma.

Infants with hypertrophic pyloric stenosis typically present at 2 to 4 weeks of age with nonbilious projectile vomiting. Hypertrophic pyloric stenosis is exceedingly rare in newborn infants and is scarcely reported in literature. Also, the diagnostic criteria for ultrasonographic measurements in newborn infants have yet to be determined.

Otogenic tension pneumocephalus caused by therapeutic lumbar CSF drainage for post-traumatic hydrocephalus: a case report.

Tension pneumocephalus occurs when a continuous flow of air accumulates in the intracranial cavity and produces a mass effect on the brain. We describe a case in which tension pneumocephalus was caused by the performance of continuous lumbar CSF drainage in a middle-aged man who had experienced a temporal bone fracture. Continuous lumbar CSF drainage is commonly performed in patients with temporal bone or basilar skull fractures to treat concomitant post-traumatic CSF rhinorrhea, CSF otorrhea, and/or hydrocephalus.

A hormonal association between estrogen metabolism and proliferative thyroid disease.

Objective: To illustrate a relationship between proliferative thyroid disease and estrogen metabolism through the analysis of urinary estrogen metabolites.

Study Design And Setting: Case-control study of 49 subjects with proliferative thyroid disorders and matching them to 49 controls. Urinary estrogen metabolite ratios were obtained, measuring 2-hydroxyestrone, an anti-proliferative metabolite, to 16alpha-hydroxyestrone, a proliferative metabolite.

Combined anterior-to-posterior and posterior-to-anterior approach to paranasal sinus surgery: an update.

Objectives: To develop an anatomically and functionally based approach to endoscopic intranasal ethmoidectomy; to develop such an approach using the salient features of the anterior-to-posterior (AP) and posterior-to-anterior (PA) intranasal sinus operations; to assess the safety of this form of ethmoidectomy in a patient population.

Study Design: Retrospective chart review of patients undergoing ethmoidectomy by the authors or by residents under their direct supervision.

Setting: University teaching hospital.