Publications by authors named "Edwin Bustamante"
One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have shown that Rac1-mediated signaling is associated with hippocampal-dependent working memory and longer-term forms of learning and memory and that Rac1 can modulate forms of both pre- and postsynaptic plasticity. How these different cognitive functions and forms of plasticity mediated by Rac1 are linked, however, is unclear.
View Article and Find Full Text PDFArticle Synopsis
- Rac1 is a key intracellular signal transducer that influences actin remodeling and is linked to working memory and learning.
- Rac1 inhibition at presynaptic terminals disrupts spatial working memory, while inhibition at postsynaptic sites affects longer-term cognitive processes.
- The study identifies specific proteins involved in presynaptic Rac1 signaling that may regulate synaptic vesicle behavior and morphology, shedding light on its role in cognitive functions.