Association of the polymorphisms rs179008 (), rs2004640 (), rs1800795 () and rs2280788 () with systemic lupus erythematosus in women of Mayan ethnicity from Yucatan.

IFN-α is the main cytokine in SLE, and single nucleotide polymorphisms (SNP) in different genes could induce it. To determine the association of rs2004640 (), rs179008 (), rs1800795 () and rs2280788 () with SLE in Mexican women with Mayan ethnicity. DNA and RNA were isolated from the peripheral blood of 110 patients and 200 healthy control subjects.

Serological and molecular analysis of parvovirus B19 infection in Mayan women with systemic lupus erythematosus in Mexico.

Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that mainly affects women, characterized by the production of autoantibodies. Its causal agent is unknown, but the combination of environmental, hormonal and genetic factors may favor the development of the disease. Parvovirus B19 has been associated with the development of SLE, since it induces the production of anti-single stranded DNA antibodies.